Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
Toxicologic Pathology
This Article
Right arrow Free Full Text (Free PDF) Free
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Newberne, P. M.
Right arrow Articles by Clark, A. J.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Newberne, P. M.
Right arrow Articles by Clark, A. J.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Journal Article

Choline Deficiency, Partial Hepatectomy, and Liver Tumors in Rats and Mice

Paul M. Newberne, D.V.M., Ph.D.

Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, MA 02139

Joao Lauro V. de Camargo, M.D., Ph.D.

Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, MA 02139

Anthony J. Clark, B.S.

Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, MA 02139

Choline deficiency (CD) increases susceptability of the rat liver to a number of hepatocellular carcinogens with a wide diversity of structure and potency. While severe CD results in micronodular cirrhosis and enhanced tumor induction, even a mild deficiency, without cirrhosis is sufficient to result in the increased carcinogenic response. The effects of CD are in part mediated via modulation of microsomal and, possibly, cytosolic enzymes responsible for activation/deactivation of carcinogens.

The B6C3F1 hybrid mouse is remarkably sensitive to initiation/promotion of liver tumors by many substances or conditions. Choline deficiency or partial hepatectomy alone, or in concert, markedly enhances liver tumor induction in the absence of any known carcinogen. These data indicate that the liver of this strain of mouse is "initiated" at or shortly after birth and can be promoted by non-carcinogenic substances or conditions.

Toxicologic Pathology, Vol. 10, No. 2, 95-106 (1982)
DOI: 10.1177/019262338201000216
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Toxicol SciHome page
A. N. Bachman, L. M. Kamendulis, and J. I. Goodman
Diethanolamine and Phenobarbital Produce an Altered Pattern of Methylation in GC-Rich Regions of DNA in B6C3F1 Mouse Hepatocytes Similar to That Resulting from Choline Deficiency
Toxicol. Sci., April 1, 2006; 90(2): 317 - 325.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
J. L. V. deCamargo, P. Punyarit, and P. M. Newberne
Early Stages of Nodular Transformation of the B6C3F1 Mouse Liver Induced by Choline Deficiency
Toxicol Pathol, January 1, 1985; 13(1): 10 - 17.
[Abstract] [PDF]

Home page
 Toxicol PatholHome page
E. Essigmann, R. G. McConnell, and P. M. Newberne
Transplantation Studies on Induced and Spontaneous Nodules from B6C3F1Mouse Liver
Toxicol Pathol, April 1, 1984; 12(3): 211 - 220.
[Abstract] [PDF]