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Toxicologic Pathology
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Chemical Carcinogens Without Mutagenic Activity: Peroxisome Proliferators As A Prototype

Janardan K. Reddy

Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611

Dante G. Scarpelli

Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611

Vadrevu Subbarao

Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611

Narendra D. Lalwani

Department of Pathology, Northwestern University Medical School, Chicago, Illinois 60611

Chemical carcinogens can be classified into two categories (i.e. mutagenic and non-mutagenic) on the basis of positive or negative evidence of DNA damage, mutagenicity or chromosomal aberrations in short-term test systems. Evidence indicates that carcinogenic peroxisome proliferators are negative in short-term test systems. This paper outlines approaches which may be useful in identifying a chemical carcinogen without mutagenic activity. It is conceivable that an alteration in DNA, if essential for initiation of neoplasia, may be mediated indirectly by the biological effects of nonmutagenic carcinogens.

Toxicologic Pathology, Vol. 11, No. 2, 172-180 (1983)
DOI: 10.1177/019262338301100209
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