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Toxicologic Pathology
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Journal Article

Liver Hyperplasia and Regression after Lead Nitrate Administration

Amedeo Columbano

Istituto di Farmacologia e Patologia Biochimica, Università degli Studi di Cagliari, Via Porcell 4, Cagliari, Italy and Istituto di Anatomia ed Istologia Patologica, Cagliari, Italy.

Giovanna M. Ledda-Columbano

Istituto di Farmacologia e Patologia Biochimica, Università degli Studi di Cagliari, Via Porcell 4, Cagliari, Italy and Istituto di Anatomia ed Istologia Patologica, Cagliari, Italy.

Piero P. Coni

Istituto di Farmacologia e Patologia Biochimica, Università degli Studi di Cagliari, Via Porcell 4, Cagliari, Italy and Istituto di Anatomia ed Istologia Patologica, Cagliari, Italy.

Massimo Vargiu

Istituto di Farmacologia e Patologia Biochimica, Università degli Studi di Cagliari, Via Porcell 4, Cagliari, Italy and Istituto di Anatomia ed Istologia Patologica, Cagliari, Italy.

Gavino Faa

Istituto di Farmacologia e Patologia Biochimica, Università degli Studi di Cagliari, Via Porcell 4, Cagliari, Italy and Istituto di Anatomia ed Istologia Patologica, Cagliari, Italy.

Paolo Pani

Istituto di Farmacologia e Patologia Biochimica, Università degli Studi di Cagliari, Via Porcell 4, Cagliari, Italy and Istituto di Anatomia ed Istologia Patologica, Cagliari, Italy.

The effect of a single intravenous injection of lead nitrate on liver, was investigated in male Wistar rats. Lead nitrate at 5 and 10 µmoles/100 g of body weight stimulated a 19-fold increase in the incorporation of 3H-thymidine into liver DNA and resulted in temporal changes in DNA synthesis, as determined by assays of specific activity. Thirty-six hours after lead nitrate administration, the incorporation of 3H-thyrnidine reached its maximum and returned to normal levels within 3 days. A significant increase in the number of cells entering mitosis at 36 hours indicated the capacity of lead to stimulate liver cell proliferation. Enlargement of the liver after lead treatment was also observed in both female Wistar rats as well in male Fischer rats. This stimulatory effect of lead on liver growth was reversible; during the involution of the liver, cell death morphologically similar to the one described as apoptosis was observed in histological sections of liver from animals sacrificed 4-7 days after lead treatment.

Toxicologic Pathology, Vol. 12, No. 1, 89-95 (1984)
DOI: 10.1177/019262338401200115
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 Toxicol PatholHome page
M. W. Roomi, A. Columbano, G. M. Ledda-Columbano, and D. S. R. Sarma
Induction of the Placental Form of Glutathione S-Transferase by Lead Nitrate Administration in Rat Liver
Toxicol Pathol, February 1, 1987; 15(2): 202 - 205.
[Abstract] [PDF]