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Toxicologic Pathology
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Journal Article

Orally Induced Adjuvant-like Arthritis in the Rat

Jack E. Gray

Pathology and Toxicology Research and Cancer and Viral Disease Research, Research Laboratories, The Upjohn Company, Kalamazoo, MI 49001

Erik R. Larsen

Pathology and Toxicology Research and Cancer and Viral Disease Research, Research Laboratories, The Upjohn Company, Kalamazoo, MI 49001

Patricia E. Fast

Pathology and Toxicology Research and Cancer and Viral Disease Research, Research Laboratories, The Upjohn Company, Kalamazoo, MI 49001

Ramon D. Hamilton

Pathology and Toxicology Research and Cancer and Viral Disease Research, Research Laboratories, The Upjohn Company, Kalamazoo, MI 49001

Adjuvant-like arthritis was produced in Sprague-Dawley rats during 14 days of oral administration of 2-amino-5-bromo-6-(3-fluorophenyl)-4(3H)-pyrimidinone. Inflammatory changes about and in the hindlimb joints were similar to those described by Pearson for adjuvant-induced polyarthritis. Lymphoid hyperplasia, elevation of serum IgG levels, and localization of fluorescein-labeled globulin in disseminated inflammatory lesions implicate an immunologic effect. Rats treated twice weekly for 64 days developed lymphocytic thyroiditis and showed less inflammation in the joints.

Toxicologic Pathology, Vol. 13, No. 4, 266-275 (1985)
DOI: 10.1177/019262338501300403
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