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Toxicologic Pathology
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Journal Article

Focal Eosinophilic Hypertrophic Cells of the Rat Pancreas

Taisan Chiu

E. I. du Pont de Nemours & Company, Central Research & Development Department, Haskell Laboratory for Toxicology & Industrial Medicine, Newark, Delaware 19711

Focal spontaneously occurring eosinophilic hypertrophic cells, histomorphologically resembling oncocytes and hepatocytes, were observed in the pancreas from 11 (0.3%) of 4,177 Sprague-Dawley rats, 3 to 26 months old. The age of these eleven rats ranged from 13 to 25 months. The incidence was not different between sexes. The altered cells were usually seen in the peri-insular area. Two types of foci, uniform and pleomorphic, were classified on the basis of uniformity of size of the altered cells within a focus. The origin and nature were not determined for the altered cells/foci reported in this study but they were not considered to be neoplastic.

Toxicologic Pathology, Vol. 15, No. 1, 1-6 (1987)
DOI: 10.1177/019262338701500101
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