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Toxicologic Pathology
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Journal Article

HMP-Shunt and Cholesterol Metabolism in Experimental Models Involving Normal and Preneoplastic Liver Growth

Amedeo Columbano

Istituto di Farmacologia e Patologia Biochimica, Via Porcell 4, 09100 Cagliari, Italy

Sandra Dessì

Istituto di Farmacologia e Patologia Biochimica, Via Porcell 4, 09100 Cagliari, Italy

Giovanna Maria Ledda-Columbano

Istituto di Farmacologia e Patologia Biochimica, Via Porcell 4, 09100 Cagliari, Italy

Caterina Chiodino

Istituto di Farmacologia e Patologia Biochimica, Via Porcell 4, 09100 Cagliari, Italy

Pierpaolo Coni

Istituto di Farmacologia e Patologia Biochimica, Via Porcell 4, 09100 Cagliari, Italy

Paolo Pani

Istituto di Farmacologia e Patologia Biochimica, Via Porcell 4, 09100 Cagliari, Italy

Kalipatnapu N. Rao

Department of Pathology, University of Pittsburgh, School of Medicine, Pittsburgh, Pennsylvania 15261, U.S.A.

Previous studies from our laboratories have shown a stimulation of HMP-shunt, cholesterol metabolism and DNA synthesis during cell proliferation. In order to understand the co-ordinated regulation of these pathways during cell growth, the above metabolic pathways were studied in: 1) liver regeneration after partial hepatectomy, 2) lead-induced liver hyperplasia, 3) liver cell proliferation induced by insulin in streptozotocin-diabetic rats, 4) liver cell proliferation in fasted rats after refeeding and, 5) hepatocyte nodules induced by a selection procedure. The results indeed indicate that changes in HMP-shunt and cholesterol metabolism occur at a very early stage during the process of normal as well as preneoplastic cell growth. The coordinated regulation between cell growth and changes in these metabolic pathways needs further study.

Toxicologic Pathology, Vol. 15, No. 1, 43-50 (1987)
DOI: 10.1177/019262338701500105
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