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Toxicologic Pathology
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Journal Article

The Physical State of Intranuclear Water and Ions: Changes During Cell Proliferation and Chemically Induced Carcinogenesis

Claudio Nicolini

Interdepartmental Center of Biomedical and Biophysico-Chemical Technologies, University of Genova, Italy and National Research Council, Genova, Italy

Pia Carlo

Interdepartmental Center of Biomedical and Biophysico-Chemical Technologies, University of Genova, Italy and National Research Council, Genova, Italy

Sandro Ridella

Interdepartmental Center of Biomedical and Biophysico-Chemical Technologies, University of Genova, Italy and National Research Council, Genova, Italy

The complex dielectric constant of small quantities of liver nuclei in various functional states was measured in the frequency range of 50–2,000 MHz using an Automatic Network Analyzer. From these measurements, through an electric model of macromolecules in solution, several quantities such as ion content, bound water, and free water have been estimated. Unique changes in the physical state of intranuclear water and ions were then apparent in the resting liver nuclei immediately following induced cell proliferation, as compared to nuclei either from early carcinogen-altered hepatocytes or from late selected carcinogen-initiated hepatocytes. Possible implications of these findings are discussed in terms of the molecular events controlling chemically-induced neoplastic transformation.

Toxicologic Pathology, Vol. 15, No. 2, 184-189 (1987)
DOI: 10.1177/019262338701500209
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