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Toxicologic Pathology
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Morphologic Stomach Findings in Rats and Mice Treated with the H2 Receptor Antagonists, ICI 125,211 and ICI 162,846

C. Spencer Streett

Pathology Section, Stuart Pharmaceuticals, Division of ICI Americas, Wilmington, Delaware 19897

John L. Robertson

Pathology Section, Stuart Pharmaceuticals, Division of ICI Americas, Wilmington, Delaware 19897

James W. Crissman

Pathology Section, Stuart Pharmaceuticals, Division of ICI Americas, Wilmington, Delaware 19897

The gross and histopathologic findings seen in the stomachs of rats and mice treated with 2 different H2 receptor antagonists are presented. Studies with the first drug, ICI 125,211, elicited dysplasia/carcinoma lesions in 17 of 828 treated rats with 12 of the 17 lesions occurring in the pyloric region of the stomach. No tumors occurred in mice on study for 18 months. Studies conducted with another drug candidate, ICI 162,846, produced neuroendocrine carcinomas in the stomach of rats and mice. Twenty-five rats out of 312 treated male and female rats had neuroendocrine carcinomas in the gastric fundus with a higher tumor incidence in females. In a 24-month mouse study with ICI 162,846, 45 of 300 treated mice developed neuroendocrine carcinomas in the gastric fundus with a higher incidence in males.

Toxicologic Pathology, Vol. 16, No. 2, 299-304 (1988)
DOI: 10.1177/019262338801600223
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