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Toxicologic Pathology
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Journal Article

Gingival Hyperplasia in Dogs Induced by Oxodipine, a Calcium Channel Blocking Agent

Trevor Waner

Life Science Research Israel, Ness Ziona, Israel

Avraham Nyska

Life Science Research Israel, Ness Ziona, Israel

Meir Nyska

Department of Orthopedic Surgery, Soroka Medical Center, Be'er Sheva, Israel

Michael Pirak

Life Science Research Israel, Ness Ziona, Israel

Mordechai Sela

Department of Oral Pathology, Hadassah University Hospital, Jerusalem, Israel

Alvaro Galiano

Instituto Quimico Biologico, Madrid, Spain

Subchronic oral exposure of dogs to Oxodipine, a new calcium channel blocker of the dihydropyridine-type, resulted in dose-related gingival hyperplastic changes. The doses at which an effect was elicited were 24 and 73 times the intended therapeutic dose for man. The effeçts were first noted after 7 weeks of treatment, and were limited to the high and intermediate dose groups of both sexes. Macroscopically, a generalized enlargement of the maxillary and mandibular facial and lingual gingivae were noted. The histological changes were similar to those described in man for Nifedipine and hydantoin-related drugs. An increase in the activity of alkaline phosphatase and a decrease in alanine aminotransferase was demonstrated. This article is the first to describe gingival hyperplasia in dogs induced in a dose-dependent manner by a calcium channel blocker.

Toxicologic Pathology, Vol. 16, No. 3, 327-332 (1988)
DOI: 10.1177/019262338801600303
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