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Toxicologic Pathology
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Journal Article

Mechanistic Approaches in the Study of Testicular Toxicity: Toxicants that Affect the Endocrine Regulation of the Testis

Robert E. Chapin

Developmental and Reproductive Toxicology Group, Systemic Toxicology Branch, National Institute of Environmental Health Sciences, National Toxicology Program, Research Triangle Park, North Carolina 27709

Jacqueline Williams

Developmental and Reproductive Toxicology Group, Systemic Toxicology Branch, National Institute of Environmental Health Sciences, National Toxicology Program, Research Triangle Park, North Carolina 27709

This review will expand on the themes presented by Heindel and Treinen (1988). As a prelude to describing where selected compounds act on the endocrine regulation of the testis and the theories about their mechanisms, we will briefly review some of the central pathways that underlie this control. After reviewing some studies that define the site of action of lead on the reproductive system, we will discuss the "signature" lesion caused by androgen deficiency, and then move on to an evaluation of the effects of an antiandrogen (flutamide) on the male reproductive system. Finally, some consideration will be given to alterations in hepatic function which modify circulating levels of androgens.

Key Words: Spermatogenesis • lead • flutamide • testicular spermatid count • androgen clearance

Toxicologic Pathology, Vol. 17, No. 2, 446-451 (1989)
DOI: 10.1177/019262338901700220
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