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Toxicologic Pathology
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Journal Article

Heterotopic Gastric Mucosa of the Small Intestine in Laboratory Beagle Dogs

Hcuiri Iwata

Division of Pathology, Biosafety Research Center, Foods, Drugs and Pesticides, 582-2, Arahama Shioshinden, Fukude-cho, Iwata-gun, Shizuoka-ken, 437-12, Japan

Chikako Arai

The 1st Department of Veterinary Pathology, Azabu University, 1-17-71, Fuchinobe, Sagamihara-shi, Kanagawa-ken, 424-01, Japan

Yoshihide Koike

Division of Pathology, Biosafety Research Center, Foods, Drugs and Pesticides, 582-2, Arahama Shioshinden, Fukude-cho, Iwata-gun, Shizuoka-ken, 437-12, Japan

Yasuhiko Hirouchi

Division of Pathology, Biosafety Research Center, Foods, Drugs and Pesticides, 582-2, Arahama Shioshinden, Fukude-cho, Iwata-gun, Shizuoka-ken, 437-12, Japan

Kazuo Kobayashi

Division of Pathology, Biosafety Research Center, Foods, Drugs and Pesticides, 582-2, Arahama Shioshinden, Fukude-cho, Iwata-gun, Shizuoka-ken, 437-12, Japan

Yasuo Nomura

The 1st Department of Veterinary Pathology, Azabu University, 1-17-71, Fuchinobe, Sagamihara-shi, Kanagawa-ken, 424-01, Japan

Makoto Enomoto

Division of Pathology, Biosafety Research Center, Foods, Drugs and Pesticides, 582-2, Arahama Shioshinden, Fukude-cho, Iwata-gun, Shizuoka-ken, 437-12, Japan

Out of the 365 young laboratory beagle dogs which were used in 17 toxicity bioassays, 15 cases (4.1%) were diagnosed as having congenital heterotopic gastric mucosa of the small intestine. Its incidence in the...male dogs (12 cases out of 187) was higher than in the female dogs (3 cases out of 178). Grossly, the lesions were seen as an ulcerous focus of the small intestine, 25 cm to 88 cm proximal to the ileocecal valve. All of the lesions were quite similar histologically and electron microscopically to the normal gastric mucosa, which are composed of the surface mucous cells, chief cells, parietal cells, mucous neck cells and basal granulated cells of the stomach. And consequently, they were considered to be that of a congenital heterotopic tissue in the small intestine. The only morphological characteristic of these lesions different from the regular gastric mucosa was an association with the tubular structure seen in the basal region of these mucosal layers. These cells were considered to be of mucous-secreting cell origin because of secreting type HI mucous evident from paradoxical concanavalin A or periodic acid Schiff stains. They seemed to be protecting the surrounding intestinal mucosa from gastric acid.

Key Words: Heterotopic gastric mucosa • ectopic • congenital • small intestine • laboratory dogs • beagles

Toxicologic Pathology, Vol. 18, No. 3, 373-379 (1990)
DOI: 10.1177/019262339001800303
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