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Assessment of the Influence of NaF or 1,25-(OH)₂ Vitamin D₃ on the Proliferative Bone Effect of an Avian Osteopetrosis Virus, MAV-2(O)

Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523

James K. Maurer

The Procter & Gamble Company, P.O. Box 398707, Cincinnati, Ohio 45239-8707

Phil H. Long

The Procter & Gamble Company, P.O. Box 398707, Cincinnati, Ohio 45239-8707

James E. Proctor

Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523

Jofrid L. Torgersen

Department of Microbiology, Colorado State University, Fort Collins, Colorado 80523

1,25-(OH)₂ vitamin D₃ (D₃) and sodium fluoride (NaF) were given to chicken embryos and newly hatched chickens infected with a slow onset strain of avian osteopetrosis-inducing virus [MAV-2(O)] to determine if either agent influenced MAV-2(O)-induced proliferation of bone. Embryos were administered MAV-2(O) and treated with: 1) up to 240 Mg NaF or up to 100 ng D₃ as embryos; 2) up to 1.8 g NaF/kg or up to 9.5 µg D₃/kg after hatching; or 3) 240 µg NaF as embryos and up to 1.8 g NaF/kg after hatching. Administration of MAV-2(O) alone resulted in expansion of the cortical diameter of bone. Coadministration of NaF or D₃ with MAV-2(O) did not influence the change in cortical diameter seen with MAV-2(O) alone at 18 days of incubation, and 3 and 6 weeks after hatching. Increased osteoid relative to bone (hyperosteoidosis), with NaF and MAV-2(O) compared to MAV-2(O) alone, and NaF compared to untreated controls reflected delayed mineralization of osteoid, a known fluoride effect. We conclude that the administration of NaF or D₃ did not influence the incidence, severity or time of onset of the MAV-2(O)-induced proliferative changes of bone.

Key Words: Sodium fluoride • retrovirus • chicken • chemical-virus interaction

Toxicologic Pathology, Vol. 18, No. 3, 380-386 (1990)
DOI: 10.1177/019262339001800304


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