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Toxicologic Pathology
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Journal Article

Spontaneously Occurring Leiomyosarcomas of the Mouse Urinary Bladder

Manik Chandra

Experimental Pathology Department, American Cyanamid Company, Pearl River, New York 10965

Charles H. Frith

Toxicology Pathology Associates, 1102 Briar Creek Road, Little Rock, Arkansas 72211

Spontaneous leiomyosarcomas of the mouse urinary bladder have not been reported. Data from 8 chronic toxicity/oncogenicity studies that included 400 male and 400 female mice were reviewed and evaluated to gather information on spontaneously occurring urinary bladder leiomyosarcomas. Three control mice from 3 different studies had leiomyosarcomas in the submucosa of the trigone area of the urinary bladder. These tumors were not connected to the surface epithelium; however, they were connected to and destroyed the smooth muscle layer of the urinary bladder. This communication describes the incidence and histopatho-logical features of these neoplasms.

Key Words: Urinary system • neoplasm • sarcoma • smooth muscle tumor • leiomyoblastoma

Toxicologic Pathology, Vol. 19, No. 2, 164-167 (1991)
DOI: 10.1177/019262339101900211
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Home page
 Toxicol PatholHome page
W. H. Halliwell
Submucosal Mesenchymal Tumors of the Mouse Urinary Bladder
Toxicol Pathol, January 1, 1998; 26(1): 128 - 136.
[Abstract] [PDF]