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Toxicologic Pathology
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Journal Article

Hyaline Glomerulopathy in B6C3F1 Mice

Zbigniew W. Wojcinski

Parke-Davis Research Institute, 2270 Speakman Drive, Mississauga, Ontario, Canada L5K 1B4

Mudher A. Avlbassam

Parke-Davis Research Institute, 2270 Speakman Drive, Mississauga, Ontario, Canada L5K 1B4

Graham S. Smith

Parke-Davis Research Institute, 2270 Speakman Drive, Mississauga, Ontario, Canada L5K 1B4

Hyaline glomerulopathy is a spontaneous disease of undetermined etiology that occurs sporadically in various strains of aging mice. In our laboratory, this disease was observed with unusual ultrastructural features as an incidental finding in 2 female B6C3F1 mice from 2 carcinogenicity bioassays. Microscopically, renal lesions were characterized by marked diffuse enlargement and prominent hyalinization of the glomeruli, equally affecting both kidneys. Affected glomeruli were PAS positive, but were negative for amyloid by the Congo red method. Immunocytochemical staining revealed weakly positive glomerular deposits with polyclonal anti-mouse IgG-IgM-IgA cocktail. Ultrastructurally, there were characteristic subendothelial osmio-philic deposits composed of loosely-packed linear structures in the glomeruli. Lamellae, which appeared as fibrils in perpendicular sections, were relatively uniform, measured 6.1-17.01 nm in diameter, and formed single or double-layered structures. The ultrastructural and immunocytochemical characteristics are suggestive of a spontaneous immune-mediated mechanism in a strain of mouse commonly used in toxicology studies.

Key Words: Hyaline glomerulopathy • ultrastructure • lamellae • kidney • mouse

Toxicologic Pathology, Vol. 19, No. 3, 224-229 (1991)
DOI: 10.1177/019262339101900304
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