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Toxicologic Pathology
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Spontaneous Renal Neoplasms in Aged Crl:CD®BR Rats

Gary M. Zwicker

Toxicology Department, Marion Merrell Dow, Inc., Indianapolis, Indiana and Cincinnati, Ohio

Randy C. Eyster

Toxicology Department, Marion Merrell Dow, Inc., Indianapolis, Indiana and Cincinnati, Ohio

Donald M. Sells

Toxicology Department, Marion Merrell Dow, Inc., Indianapolis, Indiana and Cincinnati, Ohio

Jerome H. Gass

Toxicology Department, Marion Merrell Dow, Inc., Indianapolis, Indiana and Cincinnati, Ohio

Primary neoplasms of the kidneys occurred in 11/682 male (1.6%) and 2/694 female (0.3%) Crl:CD®Br strain Sprague-Dawley rats. Eight of 13 neoplasms were of mesenchymal origin and 5 of 13 were epithelial. Five neoplasms were lipoma (3) or liposarcoma (2). Three of 13 were either hemangioma (1) or mesenchymal tumors (2). The epithelial neoplasms were carcinomas. There was no microscopic evidence of metastasis among those neoplasms judged malignant on morphologic criteria. The overall natural incidence in males was nearly double that compiled for this strain while in females the incidence was similar to that reported for other females.

Key Words: Epithelial • mesenchymal • benign • malignant • Sprague-Dawley

Toxicologic Pathology, Vol. 20, No. 1, 125-130 (1992)
DOI: 10.1177/019262339202000117
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[Abstract] [PDF]