Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
Toxicologic Pathology
This Article
Right arrow Free Full Text (Free PDF) Free
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Hall, W. C.
Right arrow Articles by Quigley, B. H.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hall, W. C.
Right arrow Articles by Quigley, B. H.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Journal Article

Histopathologic Observations in Weanling B6C3F1 Mice and F344/N Rats and Their Adult Parental Strains

William C. Hall

Pathology Associates, Inc., 15 Worman's Mill Court, Frederick, Maryland 21701

James R. Ganaway

Microbiological Associates, Inc., 5221 River Rd., Bethesda, Maryland 20816

Ghanta N. Rao

National Institute of Environmental Health Sciences, National Toxicology Program, Alexander Drive, Research Triangle Park, North Carolina 27709

Robert L. Peters

Microbiological Associates, Inc., 5221 River Rd., Bethesda, Maryland 20816

Anton M. Allen

Microbiological Associates, Inc., 5221 River Rd., Bethesda, Maryland 20816

Janet W. Luczak

Microbiological Associates, Inc., 5221 River Rd., Bethesda, Maryland 20816

Ellen M. Sandberg

Microbiological Associates, Inc., 5221 River Rd., Bethesda, Maryland 20816

B. Honey Quigley

Microbiological Associates, Inc., 5221 River Rd., Bethesda, Maryland 20816

Weanling Fischer 344/N (F344) rats and the first filial hybrid of C57BL/6 x C3H (B6C3F1) mice and retired breeders from the parental stocks of these strains were monitored over a 5-yr-period by examining the histopathology of selected organs and comparing those results to viral and mycoplasmal serology and the intestinal tract bacterial flora of each animal on an individual basis. Serology gave no evidence of viral infection, but Mycoplasma arthriditis antibodies were detected. Reactivity of serum of adult C57BL/6 female mice with control cells or media (tissue culture, TC) was seen in a significant number of mice. TC reactivity correlated positively with lymphoid perivascular infiltrates, predominantly of the lungs, suggesting an allergic response in development of the lesions. Other lesions of note consisted of Harderian gland inflammation of rats, focal necrotizing lesions of the liver of both species, and thickening of the pleura and adjacent pulmonary interstitium of weanling rats. Embolization of bacteria from the gastrointestinal tract to the liver was considered a possible cause of the liver necrosis in both species. Although lesions of the lung and Harderian gland of the rats are similar to those caused by known viral agents, the cause of the latter could not be determined as these animals were negative for viral antibodies and the former was considered to be related to incomplete pulmonary development in the young rat. Features differentiating the lesions observed in animals of this survey from those caused by viral infection are discussed.

Key Words: Allergic response • murine viruses • serology • bacteria • intestinal flora • pathology • mycoplasma

Toxicologic Pathology, Vol. 20, No. 2, 146-154 (1992)
DOI: 10.1177/019262339202000202
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?