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The Pathology of Chronic Bovine Fluorosis: A ReviewDepartment of Animal, Dairy and Veterinary Science, Utah State University, Logan, Utah 84321
Pathology Associates, Inc., 6217 Centre Park Drive, West Chester, Ohio 45069–3866
The Procter & Gamble Company, Miami Valley Laboratories, Cincinnati, Ohio 45239–8707
The Procter & Gamble Company, Miami Valley Laboratories, Cincinnati, Ohio 45239–8707 Clinical, pathologic, and analytical records from 200 cattle were reviewed to determine if long-term exposures to elevated fluorides resulted in previously unrecognized or unreported pathologic changes, especially skeletal neoplasia. Animals were part of comprehensive field and laboratory investigations of bovine fluorosis conducted by the Utah State University Agricultural Experiment Station over a 25-year period. Records indicated that over 170 cattle included in this review were exposed to dietary fluorides levels in excess of 25 ppm (dry wt), for most of their life span, and these animals exhibited bone fluoride concentrations ranging between 2,000 and 12,500 ppm (dry wt). Although dental and/or skeletal changes were present in most animals, significant soft tissue damage or neoplasia was not observed in any organ system. Renal degeneration and mineralization were slightly more prevalent in range cattleingesting high fluoride levels, but these changes were not recognized in animals that received high experimental fluoride doses. The absence of significant soft tissue damage or neoplasia in these cattle combined with results of an extensive literature review suggests that environmental fluorides are not significant factors in mammalian carcinogenesis.
Key Words: Fluoride • toxicity • chronic • non-neoplastic • cattle
Toxicologic Pathology, Vol. 20, No. 2,
274-288 (1992) |
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