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Toxicologic Pathology
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Journal Article

Environmental Tobacco Smoke: Current Assessment and Future Directions

Carr J. Smith

R. J. Reynolds Tobacco Company, Research & Development, Bowman Gray Technical Center, P.O. Box 1487, Winston-Salem, North Carolina 27102

Stephen B. Sears

R. J. Reynolds Tobacco Company, Research & Development, Bowman Gray Technical Center, P.O. Box 1487, Winston-Salem, North Carolina 27102

James C. Walker

R. J. Reynolds Tobacco Company, Research & Development, Bowman Gray Technical Center, P.O. Box 1487, Winston-Salem, North Carolina 27102

Patricia O. Deluca

R. J. Reynolds Tobacco Company, Research & Development, Bowman Gray Technical Center, P.O. Box 1487, Winston-Salem, North Carolina 27102

Scientific information on environmental tobacco smoke (ETS) is critically reviewed. Key areas addressed are: differences in chemical composition between mainstream smoke, sidestream smoke, and ETS; techniques for measurement of ETS; epidemiology; in vitro and in vivo toxicology; and chamber and field studies of perceptual or physiological effects. Questions concerning estimation of ETS exposure, suitability of various biomarkers, calculation of lifetime dose, control of confounding variables, use of meta-analysis, and the relationship between ETS concentrations and human responses all emphasize the need for additional research in order to assess potential effects of ETS on health or comfort.

Key Words: Smoke chemistry • epidemiology • toxicology • sensory • measurement techniques • environmental tobacco smoke (ETS)

Toxicologic Pathology, Vol. 20, No. 2, 289-305 (1992)
DOI: 10.1177/019262339202000217
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C. J. Smith, S. B. Sears, J. C. Walker, and P. O. Deluca
Environmental Tobacco Smoke: Current Assessment and Future Directions
Toxicol Pathol, February 1, 1992; 20(2): 289 - 305.
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