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Toxicologic Pathology
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Review Article: Quinolone Arthropathy—Acute Toxicity to Immature Articular Cartilage

Alec W. Gough

Department of Pathology and Experimental Toxicology, Warner-Lambert Company

Olajide B. Kasali

Department of Pathology and Experimental Toxicology, Warner-Lambert Company

Robert E. Sigler

Department of Pathology and Experimental Toxicology, Warner-Lambert Company

Vijaykumar Baragi

Department of Immunopathology, Parke-Davis Pharmaceutical Research Division, Warner-Lambert Company, Ann Arbor, Michigan 48105

A class effect of quinolone antibacterial agents observed during animal toxicity testing is a specific arthropathy (QAP). Despite the growing list of laboratory animals susceptible to QAP and reports of arthralgia in patients treated with quinolones, the potential for QAP development in humans remains unknown. This review discusses current concepts in the biology of articular cartilage and how these concepts elucidate QAP pathogenesis. Biomechanical forces within synovial joints and toxicokinetic properties of quinolones contribute to QAP induction. Since a limited number of mechanistic pathways exist for acute articular damage, QAP may serve as a research tool to probe the pathobiology of injury to articular cartilage.

Key Words: Dog • articular cartilage injury • xenobiotic—induced arthropathy • quinolone antibacterials • chondrocytes • cartilage matrix • proteoglycans

Toxicologic Pathology, Vol. 20, No. 3-1, 436-449 (1992)
DOI: 10.1177/019262339202000313
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