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Toxicologic Pathology
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Journal Article

Clinical Pathology Testing Recommendations for Nonclinical Toxicity and Safety Studies

Kurt Weingand

The Procter & Gamble Co., Miami Valley Laboratories, P.O. Box 398707, Cincinnati, Ohio 45239

John Bloom

Michael Carakostas

Robert Hall

Maria Helfrich

Kenneth Latimer

Barry Levine

Douglas Neptun

Alan Rebar

Katherine Stitzel

Catherine Troup

Clinical pathology testing in nonclinical toxicity and safety studies is an important part of safety assessment. In recent years, clinical laboratory testing has rapidly expanded and improved. Some government regulatory agencies provide guidelines for clinical pathology testing in nonclinical toxicity and safety studies. To improve these testing guidelines and the resultant safety assessments, the American Association for Clinical Chemistry's Division of Animal Clinical Chemistry and the American Society for Veterinary Clinical Pathology formed a joint committee to provide expert recommendations for clinical pathology testing of laboratory species involved in subchronic and chronic nonclinical toxicity and safety studies. These recommendations include technical recommendations on blood collection techniques and hematology, serum chemistry, and urinalysis tests.

Key Words: Serum chemistry • hematology • coagulation • urinalysis • blood sampling • rodents • toxicity testing • safety studies

Toxicologic Pathology, Vol. 20, No. 3-2, 539-543 (1992)
DOI: 10.1177/019262339202000317
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