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Toxicologic Pathology
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Journal Article

Spontaneous Brain and Spinal Cord/Nerve Neoplasms in Aged Sprague-Dawley Rats

Gary M. Zwicker

Marion Merrell Dow Inc., Indianapolis, Indiana, and Cincinnati, Ohio

Randy C. Eyster

Marion Merrell Dow Inc., Indianapolis, Indiana, and Cincinnati, Ohio

Donald M. Sells

Marion Merrell Dow Inc., Indianapolis, Indiana, and Cincinnati, Ohio

Jerome H. Gass

Marion Merrell Dow Inc., Indianapolis, Indiana, and Cincinnati, Ohio

Primary malignant neoplasms of the brain and spinal cord occurred in 20/718 male (2.8%) and in 13/717 female (1.8%) Crl:CD®Br strain Sprague-Dawley rats. Of 33 neoplasms, 30 were found in brain while 3 were in the spinal cord. In males and females, the most common brain neoplasm was astrocytoma (13 males, 9 females). Other neoplasms, granular cell tumor (1 male), mixed glioma (2 males, 1 female), reticulosis (1 male, 2 females), and oligodendroglioma (2 males), were especially uncommon. Spinal cord neoplasms included 2 schwannomas (1 male, 1 female) and an astrocytoma (1 male). The overall brain neoplasm incidence was similar for males (2.8%) compared to data compiled for this strain, and there was a 2-fold increase for females (1.8% vs 0.9%) compared to available incidence data.

Key Words: Nerve-sheath • glial cell • malignant • spinal nerve • Crl:CD®Br

Toxicologic Pathology, Vol. 20, No. 4, 576-584 (1992)
DOI: 10.1177/019262339202000404
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