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Multicystic Peritoneal Mesothelioma in a Fischer-344 RatNippon Institute for Biological Science, 2221–1 Shinmachi, Ome, Tokyo 198, Japan
Nippon Institute for Biological Science, 2221–1 Shinmachi, Ome, Tokyo 198, Japan
Nippon Institute for Biological Science, 2221–1 Shinmachi, Ome, Tokyo 198, Japan A spontaneous multicystic peritoneal mesothelioma was detected in a 108-wk-old male Fischer-344/DuCrj rat. Grossly, a tumor containing numerous, semitransparent, variously sized, thin-walled cysts was found on the splenic serosal surface. Microscopically, each cyst was surrounded by variable amounts of loose connective tissue. The luminal and free surfaces of the cysts were covered by a single layer of flattened or cuboidal mesothelial cells. No metastases were detected in any of the other organs. Diagnosis was supported by immunohistochemistry and ultrastructural features.
Key Words: Neoplasm mesenchymal spontaneous light microscopy electron microscopy immunohistochemistry
Toxicologic Pathology, Vol. 21, No. 1,
87-90 (1993) |
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