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Toxicologic Pathology
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Journal Article

Effect of Alternate-Day Hydrocortisone Therapy on the Immunologically Immature Rat. III: Changes in T- and B-Cell Areas in Lymph Nodes

Ahmed F. I. El Fouhil

Department of Pharmacology and Toxicology, New Jersey Medical School, UMDNJ, Newark, NJ 07103-2714

Fakhry A. Iskander

Anatomy Department, Medical School, Ain Shams University, Cairo, Egypt

Rita M. Turkall

Clinical Laboratory Sciences Department, School of Health Related Professions, Newark, New Jersey 07107-3001

The histologic effects of the alternate-day hydrocortisone therapy (400 mg/M2 from day 7 to day 19 after birth) were studied on the mesenteric lymph nodes of immunologically immature rats. In rats sacrificed 2 days following the cessation of therapy, depletion of lymphocytes of the thymus-independent area was apparent. Smaller lymphocytes were more susceptible to the effect of hydrocortisone than larger ones. The absence of primary follicles, normally present at this age, suggested a possible retardation in development of the immune system. B lymphocytes appeared to be the target of the direct lymphocytolytic effect of hydrocortisone. In rats sacrificed 23 days following the treatment, immunological maturity was achieved, indicating the reversibility of the hydrocortisone effect.

Key Words: Lewis rat • hydrocortisone sc • mesenteric lymph nodes • histology • T and B lymphocytes • immunoperoxidase

Toxicologic Pathology, Vol. 21, No. 4, 391-396 (1993)
DOI: 10.1177/019262339302100407
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