Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
Toxicologic Pathology
This Article
Right arrow Free Full Text (Free PDF) Free
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Alison, R. H.
Right arrow Articles by Prentice, D. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Alison, R. H.
Right arrow Articles by Prentice, D. E.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Journal Article

Neoplastic Lesions of Questionable Significance to Humans

Roger H. Alison

Preclinical Safety Consultants, 7 Earning Street, Godmanchester, Huntingdon, Cambridgeshire PE18 8JD, United Kingdom

Charles C. Capen

Department of Veterinary Pathobiology, The Ohio State University, 1925 Coffey Road, Columbus, Ohio 43210

David E. Prentice

Preclinical Safety Consultants, 7 Earning Street, Godmanchester, Huntingdon, Cambridgeshire PE18 8JD, United Kingdom

Many compounds giving a positive result in animal carcinogenicity studies through mechanisms involving secondary carcinogenesis pose little or no risk to humans. This article provides an overview of current understanding, with particular reference to renal tumors in male rats with {alpha}2µ-globulin nephropathy, urinary bladder neoplasia in rodents, mesovarian leiomyomas induced in rats by β2-receptor stimulants, carcinoid tumors in the rodent stomach induced by prolonged suppression of acid secretion, thyroid follicular cell tumors in rodents, canine mammary neoplasia due to administration of progestagens, rodent mammary neoplasia induced by estrogens, uterine endometrial carcinomas of rats induced by dopamine agonists, Leydig cell tumors in the testis of rats, and ovarian tubulostromal adenomas in mice. A positive result on a rodent carcinogenicity study should not automatically preclude further development of a compound; future progress in this field should increase the accuracy of the rodent carcinogenicity study as a tool in human safety assessment.

Key Words: Secondary carcinogenesis • safety assessment • neoplasia • kidney • stomach • mammary gland • ovary • testis

Toxicologic Pathology, Vol. 22, No. 2, 179-186 (1994)
DOI: 10.1177/019262339402200211
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Toxicol SciHome page
J. A. Dill, K. M. Lee, R. A. Renne, R. A. Miller, A. F. Fuciarelli, K. M. Gideon, P. C. Chan, L. T. Burka, and J. H. Roycroft
{alpha}2u-Globulin Nephropathy and Carcinogenicity following Exposure to Decalin (Decahydronaphthalene) in F344/N Rats
Toxicol. Sci., April 1, 2003; 72(2): 223 - 234.
[Abstract] [Full Text] [PDF]

Home page
 Toxicol PatholHome page
G. G. Long, I. R. Cohen, C. L. Gries, J. K. Young, P. C. Francis, and C. C. Capen
Proliferative Lesions of Ovarian Granulosa Cells and Reversible Hormonal Changes Induced in Rats by a Selective Estrogen Receptor Modulator
Toxicol Pathol, October 1, 2001; 29(6): 719 - 726.
[Abstract] [PDF]

Home page
 Toxicol PatholHome page
G. G. Long, I. R. Cohen, C. L. Gries, J. K. Young, P. C. Francis, and C. C. Capen
Proliferative Lesions of Ovarian Granulosa Cells and Reversible Hormonal Changes Induced in Rats by a Selective Estrogen Receptor Modulator
Toxicol Pathol, June 1, 2001; 29(4): 403 - 410.
[Abstract] [PDF]

Home page
 Toxicol PatholHome page
R. M. David, M. R. Moore, D. C. Finney, and D. Guest
Reversibility of the Chronic Effects of Di(2-ethylhexyl)phthalate
Toxicol Pathol, June 1, 2001; 29(4): 430 - 439.
[Abstract] [PDF]

Home page
 Toxicol PatholHome page
C. C. Capen
Overview of Structural and Functional Lesions in Endocrine Organs of Animals
Toxicol Pathol, January 1, 2001; 29(1): 8 - 33.
[Abstract] [PDF]

Home page
 Toxicol SciHome page
R. M. David, M. R. Moore, D. C. Finney, and D. Guest
Chronic Toxicity of Di(2-ethylhexyl)phthalate in Rats
Toxicol. Sci., June 1, 2000; 55(2): 433 - 443.
[Abstract] [Full Text] [PDF]

Home page
 International Journal of ToxicologyHome page
B. S. Lynch, D. W. Bryant, G. J. Hook, E. R. Nestmann, and I. C. Munro
Carcinogenicity of Monochloro-1,2-Propanediol ({alpha}-Chlorohydrin, 3-MCPD)
International Journal of Toxicology, January 1, 1998; 17(1): 47 - 76.
[Abstract] [PDF]

Home page
 International Journal of ToxicologyHome page
T. S. Davies and A. Monro
Marketed Human Pharmaceuticals Reported to be Tumorigenic in Rodents
International Journal of Toxicology, April 1, 1995; 14(2): 90 - 107.
[Abstract] [PDF]