Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
Toxicologic Pathology
This Article
Right arrow Free Full Text (Free PDF) Free
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Vogelbein, W. K.
Right arrow Articles by Fournie, J. W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Vogelbein, W. K.
Right arrow Articles by Fournie, J. W.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Journal Article

Ultrastructure of Normal and Neoplastic Exocrine Pancreas in the Mummichog, Fundulus heteroclitus

Wolfgang K. Vogelbein

School of Marine Science, Virginia Institute of Marine Science, The College of William and Mary, Gloucester Point, Virginia 23062

John W. Fournie

U.S. Environmental Protection Agency, Center for Marine and Estuarine Disease Research, 1 Sabine Island Drive, Gulf Breeze, Florida 32561

The ultrastructure of exocrine pancreatic neoplasms occurring in the mummichog, Fundulus heteroclitus, from a creosote-contaminated site in the Elizabeth River, Virginia, is described and related to nonneoplastic exocrine pancreas. Normal mummichog pancreas was an anastomosing tubular gland, with parenchymal cells organized as branched, anastomosing tubules around a central ductular system. The pancreatic ductular system consisted sequentially of terminal canalicular lumens lined by acinar cells, pancreatic preductules formed by an acinar and a centroductular cell, pancreatic ductules lined by 2 centroductular cells, and pancreatic ducts lined by cuboidal or columnar epithelial cells resting on a basal lamina and stromal sheath. Acinar cell adenomas retained the normal tubular organization and relationship between acinar and centroductular cells. Tumor cells exhibited nuclear pleomorphism but contained a full complement of normal zymogen granules and rough endoplasmic reticulum (RER). Some adenomas exhibited necrosis and cellular degeneration. Acinar cell carcinomas ranged from well to poorly differentiated. They exhibited loss of cell polarity, moderate to severe nuclear pleomorphism, extensive variation in size, shape, and number of zymogen granules, variability in RER content, and cellular degeneration. Acinar cell neoplasms in the mummichog were similar to those induced chemically in other fishes and certain mammals, suggesting that this fish population has been exposed to potent chemical carcinogens and that the species may be an effective indicator of polluted estuarine environments.

Key Words: Exocrine pancreas • neoplasia • ultrastructure • fish

Toxicologic Pathology, Vol. 22, No. 3, 248-260 (1994)
DOI: 10.1177/019262339402200303
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Toxicol PatholHome page
J. M. Law
Issues Related to the Use of Fish Models in Toxicologic Pathology: Session Introduction
Toxicol Pathol, January 1, 2003; 31(1_suppl): 49 - 52.
[Abstract] [PDF]

Home page
 Toxicol PatholHome page
T. E. Bunton
Review Article: Experimental Chemical Carcinogenesis in Fish
Toxicol Pathol, September 1, 1996; 24(5): 603 - 618.
[Abstract] [PDF]