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Nasal Diagrams: A Tool for Recording the Distribution of Nasal Lesions in Rats and Mice
Stéphane Mery
CT, Research Triangle Park, North Carolina 27709
Elizabeth A. Gross
CT, Research Triangle Park, North Carolina 27709
Donald R. Joyner
CT, Research Triangle Park, North Carolina 27709
Matthew Godo
CT, Research Triangle Park, North Carolina 27709
Kevin T. Morgan
CT, Research Triangle Park, North Carolina 27709
Knowledge of patterns of lesion distribution can provide insight into the relative roles played by regional tissue dose and local tissue susceptibility in toxic responses to xenobiotics in the nose and assist assessment of potential human risk. A consistent approach is needed for recording lesion distribution patterns in the complex nasal airways of rats and mice. The present work provides a series of diagrams of the nasal passages of the Fischer-344 rat and B6C3F1 mouse, designed for mapping nasal lesions. The diagrams present each of the major cross-sectional airway profiles, provide adequate space for nasal mucosal lesion recording, and are suitable for duplication in a commercial photocopier. Sagittal diagrams are also provided to permit transfer oflesion location data observed in transverse sections onto the long axis of the nose. The distribution of lesions induced by a selected range of xenobiotics is presented. Approaches to application of the diagrams and interpretation of results obtained are discussed in relation to factors responsible for lesion distribution in the nose and their relevance to interspecies extrapolation. A modified approach to anatomical classification of the ethmoturbinates of the rodent is also presented.
Key Words: Pathology • dosimetry • anatomy • histology • toxicology • mapping lesions • olfaction
Toxicologic Pathology, Vol. 22, No. 4,
353-372 (1994)
DOI: 10.1177/019262339402200402
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|
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|
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|
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|
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|
|
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|
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|
|
|
|
|
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31(4):
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[Abstract]
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|
|
|
|
|
|
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30(3):
306 - 311.
[Abstract]
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|
|
|
|
|
|
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66(1):
7 - 15.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
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30(2):
200 - 208.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. B. Genter, D. M. Burman, M. W. Dingeldein, I. Clough, and B. Bolon
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28(6):
770 - 781.
[Abstract]
[PDF]
|
|
|
|
|
|
|
K. A. Brenneman, R. Arden James, E. A. Gross, and D. C. Dorman
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March 1, 2000;
28(2):
326 - 333.
[Abstract]
[PDF]
|
|
|
|
|
|
|
J. F. Hardisty, R. H. Garman, J. R. Harkema, L. G. Lomax, and K. T. Morgan
Histopathology of Nasal Olfactory Mucosa from Selected Inhalation Toxicity Studies Conducted with Volatile Chemicals
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November 1, 1999;
27(6):
618 - 627.
[Abstract]
[PDF]
|
|
|
|
|
|
|
M. V. Pino, M. G. Valerio, G. K. Miller, J. L. Larson, D. L. Rosolia, Z. Jayyosi, C. N. Crouch, J. Q. Trojanowski, and L. E. Geiger
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July 1, 1999;
27(4):
383 - 394.
[Abstract]
[PDF]
|
|
|
|
|
|
|
K. M. Walsh and C. L. Courtney
Nasal Toxicity of CI-959, A Novel Anti-inflammatory Drug, in Wistar Rats and Beagle Dogs
Toxicol Pathol,
November 1, 1998;
26(6):
717 - 723.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R. Tarran, M. A. Gray, M. J. Evans, W. H. Colledge, R. Ratcliff, and B. E. Argent
Basal chloride currents in murine airway epithelial cells: modulation by CFTR
Am J Physiol Cell Physiol,
April 1, 1998;
274(4):
C904 - C913.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Mancuso, A. Giovanetti, and E. B Brittebo
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Toxicol Pathol,
March 1, 1997;
25(2):
186 - 194.
[Abstract]
[PDF]
|
|
|
|
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