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Induction of the Renal Peiyic and Ureteral Carcinomas by N-Butyl-N-(4-Hydroxybutyl)nitrosamine in SD/cShi Rats with Spontaneous Hydronephrosis

Aburahi Laboratories, Shionogi & Co., Ltd., Koka-cho, Shiga 520-34, Japan

Motoko Hosono

Aburahi Laboratories, Shionogi & Co., Ltd., Koka-cho, Shiga 520-34, Japan

Setsuko Machino

Aburahi Laboratories, Shionogi & Co., Ltd., Koka-cho, Shiga 520-34, Japan

Sachiko Nakai

Aburahi Laboratories, Shionogi & Co., Ltd., Koka-cho, Shiga 520-34, Japan

Susumu Makino

Aburahi Laboratories, Shionogi & Co., Ltd., Koka-cho, Shiga 520-34, Japan

Hiroyuki Nakao

Aburahi Laboratories, Shionogi & Co., Ltd., Koka-cho, Shiga 520-34, Japan

Yasuyoshi Takeuchi

Aburahi Laboratories, Shionogi & Co., Ltd., Koka-cho, Shiga 520-34, Japan

Reiji Takeda

Aburahi Laboratories, Shionogi & Co., Ltd., Koka-cho, Shiga 520-34, Japan

Takashi Murai

First Department of Pathology, Osaka City University Medical School, Asahi-machi, Abeno-ku, Osaka 545, Japan

Shoji Fukushima

First Department of Pathology, Osaka City University Medical School, Asahi-machi, Abeno-ku, Osaka 545, Japan

We attempted to establish an animal model for renal pelvic and ureteral carcinomas. In Experiment 1, Sprague-Dawley (SD)/cShi and SD/gShi strains of male and female rats and Fischer-344 (F-344) DuCrj and LEW/Crj strains of male rats, 6 wk old, were given 0.05% N-butyl-N-(4-hydroxybutyl)nitrosamine (BBN) for 12 wk and then treated without chemical for 10 wk. Only the SD/cShi strain. which has spontaneous hydronephrosis and hydroureter, showed high incidences of carcinomas in the renal pelvises and ureters, whereas the other strains did not. In Experiment 2, SD/cShi and Crj:CD strains of male and female rats. 6 wk old, were exposed to 0.05% BBN for 20 wk. Both sexes of SD/cShi rats had high incidences of bilateral carcinomas in renal pelvises and/or ureters associated with urinary bladder carcinomas, whereas both sexes of Crj:CD rats had urinary bladder tumors only. These results indicate that the SD/cShi strain may be a suitable animal for the induction of renal pelvic and ureteral carcinomas that appear to depend on urine stagnation secondary to hydronephrosis and hydroureter.

Key Words: Upper urothelium • transitional cell carcinoma • carcinogen • oral administration • hydroureter • stagnation of urine flow • animal model

Toxicologic Pathology, Vol. 22, No. 4, 373-380 (1994)
DOI: 10.1177/019262339402200403


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