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Toxicologic Pathology
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Journal Article

Carcinogenicity of Dietary Dimethylnitrosomorpholine, N-methyl-N'-Nitro-N-Nitrosoguanidine, and Dibromoethane in Rainbow Trout

Jerry D. Hendricks

Marine/Freshwater Biomedical Sciences Center and Department of Food Science and Technology, Oregon State University, Corvallis, Oregon 97331

Dennis W. Shelton

Marine/Freshwater Biomedical Sciences Center and Department of Food Science and Technology, Oregon State University, Corvallis, Oregon 97331

Patricia M. Loveland

Marine/Freshwater Biomedical Sciences Center and Department of Food Science and Technology, Oregon State University, Corvallis, Oregon 97331

Cliff B. Pereira

Department of Statistics, Oregon State University, Corvallis, Oregon 97331

George S. Bailey

Marine/Freshwater Biomedical Sciences Center and Department of Food Science and Technology, Oregon State University, Corvallis, Oregon 97331

Eighteen-mo feeding trials of rainbow trout were used to test the carcinogenicity of 5 chemicals in this species. A single exposure level was used for each substance. The doses and chemicals tested were 1,556 ppm 2,6-dimethylnltrosomorpholine (DMNM), 500 ppm N-methyl-N'-nitro-N-nitrosoguanidine (MNNG), 2,000 ppm 1,2-dibromoethane (DBE), 2,000 ppm 1,1-dichloroethylene (DCE), and 200 ppm cyclophosphamide (CP). Liver and/or glandular stomach neoplasms were produced by DMNM (liver and stomach), MNNG (stomach), and DBE (chiefly, stomach tumors). In addition, DMNM produced a low incidence of swimbladder papillomas and caused testicular atrophy in 50% of treated males. DCE and CP produced no neoplasms at the exposure levels used. No evidence of other chronic toxicity was seen for any of the 5 compounds.

Key Words: Hepatocellular adenoma • hepatocellular carcinoma • glandular stomach papillary adenomas • swimbladder adenomas • testicular atrophy

Toxicologic Pathology, Vol. 23, No. 4, 447-457 (1995)
DOI: 10.1177/019262339502300402
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