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Toxicologic Pathology
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Journal Article

Quantitative Microscopy of Hepatic Changes Induced by Phenethyl Isothiocyanate in Fischer-344 Rats Fed Either a Cereal-Based Diet or a Purified Diet

Robert H. Gray

Department of Environmental and Industrial Health, University of Michigan, Ann Arbor, Michigan 48109

Gabriela Adam-Rodwell

Department of Pathology, Medical College of Ohio, Toledo, Ohio 43699

Dorina Maris

Department of Environmental and Industrial Health, University of Michigan, Ann Arbor, Michigan 48109

Jeffrey R. Haskins

Department of Environmental and Industrial Health, University of Michigan, Ann Arbor, Michigan 48109

Gary D. Stoner

Department of Pathology, Medical College of Ohio, Toledo, Ohio 43699

Hepatic changes induced by phenethyl isothiocyanate (PEITC) in the liver of rats were determined by quantitative microscopy. Groups of male Fischer-344 rats were fed either a standard, cereal-based diet (Wayne rodent meal) or a purified diet (AIN-76A) containing PEITC at concentrations of 0.75 and 6.0 mmol/kg for 13 wk. Severe hepatic lipidosis was observed in control rats fed the purified diet. Addition of PEITC to the purified diet significantly reduced lipid content in hepatocytes. In contrast, lipid content in the liver of the rats fed the cereal-based diet containing PEITC was greater than in control rats maintained on the same diet. In addition, dose-related reductions in hepatocyte, lipid droplet, peroxisome, and mitochondrial volumes were observed in PEITC-treated rats fed the cereal-based diet. These results indicate that PEITC exerts differential effects on the liver of rats fed either the cereal-based or purified diet.

Key Words: Morphometric analysis • AIN-76A purified diet • hepatic fatty change • liver • rat

Toxicologic Pathology, Vol. 23, No. 6, 644-652 (1995)
DOI: 10.1177/019262339502300602
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