This Article Free Full Text (Free PDF) Free References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Losco, P. E. Search for Related Content PubMed PubMed Citation Articles by Losco, P. E. Social Bookmarking                         What's this?

Dental Dysplasia in Rats and Mice

Bushy Run Research Center, Export, Pennsylvania 15632

Malformations of the maxillary incisors, diagnosed as dental dysplasia, were observed as a spontaneous background lesion in 3% (females) to 9% (males) of CD-1® mice and 14.5% (females) to 10.5% (males) of CD@ (Sprague-Dawley) rats in a chronic inhalation study. Lesions were reported grossly as overgrown, maloccluded, or malformed incisors. Microscopic findings included tooth pulp and periodontal abscesses, fractured and necrotic teeth, periodontal cysts, malformations of the incisor roots, and expansile masses, including odontomas, of the incisor roots. Development of lesions followed a pattern of tooth pulp necrosis and/or traumatic disruption of the epithelial root sheath at the base of the tooth. Feeding a powdered ration, which reduced the normal wearing of the incisors, and repeated clipping of overgrown incisors were believed to contribute to the incidence of disease.

Key Words: Dental disease • incisors • odontoma • rodents • dental malformation • dental harnartoma • nasal cavity toxicology • odontodysplasia

Toxicologic Pathology, Vol. 23, No. 6, 677-688 (1995)
DOI: 10.1177/019262339502300605


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				R. Renne, A. Brix, J. Harkema, R. Herbert, B. Kittel, D. Lewis, T. March, K. Nagano, M. Pino, S. Rittinghausen, et al. Proliferative and Nonproliferative Lesions of the Rat and Mouse Respiratory Tract Toxicol Pathol, December 1, 2009; 37(7_suppl): 5S - 73S. [Abstract] [Full Text] [PDF]

				P. H. Long, R. A. Herbert, and A. Nyska Hexachlorobenzene-Induced Incisor Degeneration in Sprague--Dawley Rats Toxicol Pathol, January 1, 2004; 32(1): 35 - 40. [Abstract] [PDF]

				O. Katsuta, N. Hoshino, M. Takeda, A. Ono, and M. Tsuchitani A Spontaneous Mutation: Amelogenesis Imperfecta with Cysts in Rats Toxicol Pathol, June 1, 2003; 31(4): 411 - 416. [Abstract] [PDF]

				P. H. Long and R. A. Herbert Epithelial-Induced Intrapulpal Denticles in B6C3F1 Mice Toxicol Pathol, October 1, 2002; 30(6): 744 - 748. [Abstract] [PDF]

				D. C. Haines, S. Chattopadhyay, and J. M. Ward Pathology of Aging B6;129 Mice Toxicol Pathol, October 1, 2001; 29(6): 653 - 661. [Abstract] [PDF]

				P. H. Long, R. R. Maronpot, B. I. Ghanayem, J. H. Roycroft, and A. Nyska Dental Pulp Infarction in Female Rats Following Inhalation Exposure to 2-Butoxyethanol Toxicol Pathol, March 1, 2000; 28(2): 246 - 252. [Abstract] [PDF]

				Y. Sakura Periodontal Inflammatory and Cystlike Lesions in BDF1 and B6C3F1 Mice Veterinary Pathology, September 1, 1997; 34(5): 460 - 463. [Abstract] [PDF]

				T. Thyagarajan, T. Sreenath, A. Cho, J. T. Wright, and A. B. Kulkarni Reduced Expression of Dentin Sialophosphoprotein Is Associated with Dysplastic Dentin in Mice Overexpressing Transforming Growth Factor-beta 1 in Teeth J. Biol. Chem., March 30, 2001; 276(14): 11016 - 11020. [Abstract] [Full Text] [PDF]