This Article Free Full Text (Free PDF) Free References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Katsuta, O. Articles by Umemura, T. Search for Related Content PubMed PubMed Citation Articles by Katsuta, O. Articles by Umemura, T. Social Bookmarking                         What's this?

Cadmium-Induced Dental Lesions in Ovariectomized Rats

Mitsubishi Chemical Safety Institute Ltd., 14 Sunayama, Hasaki-machi, Kashima-gun, Ibaraki 314-02, Japan

Hideaki Hiratsuka

Mitsubishi Chemical Safety Institute Ltd., 14 Sunayama, Hasaki-machi, Kashima-gun, Ibaraki 314-02, Japan

Junko Matsumoto

Mitsubishi Chemical Safety Institute Ltd., 14 Sunayama, Hasaki-machi, Kashima-gun, Ibaraki 314-02, Japan

Minoru Tsuchitani

Mitsubishi Chemical Safety Institute Ltd., 14 Sunayama, Hasaki-machi, Kashima-gun, Ibaraki 314-02, Japan

Takashi Umemura

Department of Veterinary Pathology, Faculty of Agriculture, Tottori University, Koyama-cho, Tottori-shi, Tottori 680, Japan

The effects of cadmium chloride on both incisor and molar teeth of ovariectomized female rats were studied histopathologically. The rats were injected intravenously with the compound at doses of 1.0 and 2.0 mg/kg, 5 days/wk. Six rats per group were sacrificed at 4, 8, and 13 wk.

Discoloration of the incisors was observed in the rats of the 2.0-mg/kg group from 8 wk. Histopathologic examination of the incisor demonstrated decreased iron-containing pigment in ameloblasts and destruction of the enamel organ. These changes were accompanied with accumulation of cadmium and loss of iron in the teeth. Necrosis of the dental pulp occurred from the coronal end of both the incisor and molar teeth extended to the apical, deep portion of the teeth. The dental pulp of the molar teeth, which is shorter than that of the incisor, was mildly affected by cadmium intoxication. These findings suggested that intradental ischemia due to cadmium toxicity may have contributed to the development of the pulpal necrosis.

Key Words: Cadmium toxicity • degeneration of enamel organ • incisor and molar teeth • necrosis of dental pulp • Itai-itai disease

Toxicologic Pathology, Vol. 24, No. 4, 451-457 (1996)
DOI: 10.1177/019262339602400407


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				O. Katsuta, N. Hoshino, M. Takeda, A. Ono, and M. Tsuchitani A Spontaneous Mutation: Amelogenesis Imperfecta with Cysts in Rats Toxicol Pathol, June 1, 2003; 31(4): 411 - 416. [Abstract] [PDF]

				H. Satoh, Y. Uesugi, T. Kawabata, K. Mori, F. Fuj, Y. Kashimoto, T. Kajimura, and K. Furuhama Morphological Classification of Dental Lesions Induced by Various Antitumor Drugs in Mice Toxicol Pathol, April 1, 2001; 29(3): 292 - 299. [Abstract] [PDF]

				S. S. Habeebu, J. Liu, Y. Liu, and C. D. Klaassen Metallothionein-Null Mice Are More Susceptible Than Wild-Type Mice to Chronic CdCl2-Induced Bone Injury Toxicol. Sci., July 1, 2000; 56(1): 211 - 219. [Abstract] [Full Text] [PDF]