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Toxicologic Pathology
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Journal Article

Equivocal Evidence of Complete Carcinogenicity after Repeated Infection of Syrian Hamsters with Opisthorchis viverrini

Witaya Thamavit

Carcinogenesis Research Unit, Department of Pathobiology, Faculty of Science, Mahidol University, Rama VI Road, Bangkok 10400, Thailand

Danai Tiwawech

Biology Section, Research Division, National Cancer Institute, Rama VI Road, Bangkok 10400, Thailand

Malcolm A. Moore

First Department of Pathology, Nagoya City University Medical School, 1-Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467, Japan

Nobuyuki Ito

First Department of Pathology, Nagoya City University Medical School, 1-Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467, Japan

Tomoyuki Shirai

First Department of Pathology, Nagoya City University Medical School, 1-Kawasumi, Mizuho-cho, Mizuho-ku, Nagoya 467, Japan

The effects of repeated infection with Opisthorchis viverrini on liver lesion development in male and female Syrian hamsters were investigated over a 1-yr period. Ten monthly intragastric applications of 50, 25, 13, or 0 parasite metacercariae resulted in pronounced proliferative and inflammatory lesions involving the first- and second-order ducts in response to the presence of adult worms. Despite the development of small numbers of putative preneoplastic areas of cholangiofibrosis and morphologically altered hepatocellular foci, no neoplastic lesions were evident at sacrifice after 1 yr. The results thus suggest that parasite infestation is itself not strongly carcinogenic if at all but, rather, that it exerts a marked promoting influence on cholangiocellular and hepatocellular tumor development in the hamster via chronic irritation and increased cell turnover.

Key Words: Opisthorchiasis • liver cancer • proliferation • inflammation

Toxicologic Pathology, Vol. 24, No. 4, 493-497 (1996)
DOI: 10.1177/019262339602400412
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