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Classification of Cystic Keratinizing Squamous Lesions of the Rat Lung: Report of a Workshop

Sponsored by the Deutsche Forschungsgemeinschaft, Hannover, Germany, on February 15-17, 1995

Michael Brockmann

Sponsored by the Deutsche Forschungsgemeinschaft, Hannover, Germany, on February 15-17, 1995

William W. Carlton

Sponsored by the Deutsche Forschungsgemeinschaft, Hannover, Germany, on February 15-17, 1995

John M.G. Davis

Sponsored by the Deutsche Forschungsgemeinschaft, Hannover, Germany, on February 15-17, 1995

Donald L. Dungworth

Sponsored by the Deutsche Forschungsgemeinschaft, Hannover, Germany, on February 15-17, 1995

Fletcher F. Hahn

Sponsored by the Deutsche Forschungsgemeinschaft, Hannover, Germany, on February 15-17, 1995

Ulrich Mohr

Sponsored by the Deutsche Forschungsgemeinschaft, Hannover, Germany, on February 15-17, 1995

Hans-Bernhard Richter Reichhelm

Sponsored by the Deutsche Forschungsgemeinschaft, Hannover, Germany, on February 15-17, 1995

Vladimir S. Turusov

Sponsored by the Deutsche Forschungsgemeinschaft, Hannover, Germany, on February 15-17, 1995

Bernard M. Wagner

Sponsored by the Deutsche Forschungsgemeinschaft, Hannover, Germany, on February 15-17, 1995

An international workshop of toxicologic pathologists reviewed cystic keratinizing squamous lesions of the rat lung. These lesions develop in response to the chronic inhalation of diverse particulate materials. Controversy exists over the biological significance of these changes and their relevance to humans. For the first time, in one place, a group of pathologists analyzed slides from all available studies. The workshop reached a consensus as to classification of these unique pulmonary tissue responses and offers diagnostic criteria for application. Although additional research is needed, this working classification scheme should serve as a practical interim approach for pathologists and regulatory agencies.

Key Words: Inhalation toxicology • rat pulmonary tumors • species specific pulmonary responses

Toxicologic Pathology, Vol. 24, No. 5, 564-572 (1996)
DOI: 10.1177/019262339602400505


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