|
Sign In to gain access to subscriptions and/or personal tools.
|
Possible Mechanisms Underlying the Antiaging Actions of Caloric Restriction
Edward J. Masoro
University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, San Antonio, Texas 78284-7756
Restricting the food intake of mice and rats to well below that of ad libitum-fed animals markedly slows the aging processes. This action is reflected in an increase in longevity, a decrease in the age-associated increase in age-specific mortality rate, the maintenance of the physiological processes in a youthful state even at advanced ages, and the delaying of the onset or slowing of the progression or both of most age-associated diseases. The dietary factor responsible is the reduction in energy (caloric) intake. Many hypotheses have been proposed regarding mechanisms underlying this antiaging action. Hypotheses relating the antiaging action to the retardation of growth and development, the reduction of adipose mass, and the reduction of metabolic rate have been found to be wanting. Two of the proposed hypotheses have some evidence in their support. One involves the altered metabolic characteristics of glucose fuel use and of oxidative metabolism. The other relates to the enhanced ability of the rodents restricted in food intake to cope with challenges, which in turn has been linked to the glucocorticoid system and to the heat-shock protein system.
Key Words: Growth • body fat • metabolic rate • glucose-insulin system • oxidative damage • glucocorticoids • heat-shock proteins
Toxicologic Pathology, Vol. 24, No. 6,
738-741 (1996)
DOI: 10.1177/019262339602400617
 CiteULike  Complore  Connotea  Del.icio.us  Digg  Reddit  Technorati  Twitter What's this?
This article has been cited by other articles:
|
|
|
|
 
K. P. Keenan, C.-M. Hoe, L. Mixson, C. L. Mccoy, J. B. Coleman, B. A. Mattson, G. A. Ballam, L. A. Gumprecht, and K. A. Soper
Diabesity: A Polygenic Model of Dietary-Induced Obesity from Ad Libitum Overfeeding of Sprague-Dawley Rats and Its Modulation by Moderate and Marked Dietary Restriction
Toxicol Pathol,
October 1, 2005;
33(6):
650 - 674.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. A. Evans, A. D. Parsons, and J. M. Overton
Homeostatic responses to caloric restriction: influence of background metabolic rate
J Appl Physiol,
October 1, 2005;
99(4):
1336 - 1342.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Molon-Noblot, M.-F. Hubert, C.-M. Hoe, K. Keenan, and P. Laroque
The Effects of Ad Libitum Feeding and Marked Dietary Restriction on Spontaneous Skeletal Muscle Pathology in Sprague-Dawley Rats
Toxicol Pathol,
August 1, 2005;
33(5):
600 - 608.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
E.-S. Han and M. Hickey
Microarray Evaluation of Dietary Restriction
J. Nutr.,
June 1, 2005;
135(6):
1343 - 1346.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. K. Quarrie and K. T. Riabowol
Murine Models of Life Span Extension
Sci. Aging Knowl. Environ.,
August 4, 2004;
2004(31):
re5 - re5.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
S. Molon-Noblot, P. Laroque, J. B. Coleman, C.-M. Hoe, and K. P. Keenan
The Effects of Ad Libitum Overfeeding and Moderate and Marked Dietary Restriction on Age-Related Spontaneous Pituitary Gland Pathology in Sprague--Dawley Rats
Toxicol Pathol,
April 1, 2003;
31(3):
310 - 320.
[Abstract]
[PDF]
|
|
|
|
|
|
|
E. J. Masoro
Subfield History: Caloric Restriction, Slowing Aging, and Extending Life
Sci. Aging Knowl. Environ.,
February 26, 2003;
2003(8):
re2 - 2.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
I. Gabriely, X. H. Ma, X. M. Yang, G. Atzmon, M. W. Rajala, A. H. Berg, P. Scherer, L. Rossetti, and N. Barzilai
Removal of Visceral Fat Prevents Insulin Resistance and Glucose Intolerance of Aging: An Adipokine-Mediated Process?
Diabetes,
October 1, 2002;
51(10):
2951 - 2958.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
M. Z. Tucker and L. P. Turcotte
Brief food restriction increases FA oxidation and glycogen synthesis under insulin-stimulated conditions
Am J Physiol Regulatory Integrative Comp Physiol,
April 1, 2002;
282(4):
R1210 - R1218.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
J. F. Mahler
Mutant Models of Prolonged Life Span
Toxicol Pathol,
October 1, 2001;
29(6):
673 - 676.
[Abstract]
[PDF]
|
|
|
|
|
|
|
S. Molon-Noblot, K. P. Keenan, J. B. Coleman, C.-M. Hoe, and P. Laroque
The Effects of Ad Libitum Overfeeding and Moderate and Marked Dietary Restriction on Age-Related Spontaneous Pancreatic Islet Pathology in Sprague--Dawley Rats
Toxicol Pathol,
April 1, 2001;
29(3):
353 - 362.
[Abstract]
[PDF]
|
|
|
|
|
|
|
R. Weindruch, K. P. Keenan, J. M. Carney, G. Fernandes, R. J. Feuers, R. A. Floyd, J. B. Halter, J. J. Ramsey, A. Richardson, G. S. Roth, et al.
Caloric Restriction Mimetics: Metabolic Interventions
J. Gerontol. A Biol. Sci. Med. Sci.,
March 1, 2001;
56(90001):
20 - 33.
[Abstract]
[Full Text]
[PDF]
|
|
|
|
|
|
|
Letters to the Editor
Toxicol Pathol,
February 1, 2001;
29(2):
274 - 276.
[PDF]
|
|
|
|
|
|
|
M. J. Forster, B. H. Sohal, and R. S. Sohal
Reversible Effects of Long-Term Caloric Restriction on Protein Oxidative Damage
J. Gerontol. A Biol. Sci. Med. Sci.,
November 1, 2000;
55(11):
522B - 529.
[Abstract]
[Full Text]
|
|
|
|
|
|
|
K P Keenan
BSELLE newsletter commentary: does caloric restriction induce hormesis?
Human and Experimental Toxicology,
June 1, 2000;
19(6):
335 - 337.
[PDF]
|
|
|
|
|
|
|
M. Kemi, K. P. Keenan, C. Mccoy, C.-M. Hoe, K. A. Soper, G. C. Ballam, and M. J. Van Zwieten
The Relative Protective Effects of Moderate Dietary Restriction versus Dietary Modification on Spontaneous Cardiomyopathy in Male Sprague-Dawley Rats
Toxicol Pathol,
March 1, 2000;
28(2):
285 - 296.
[Abstract]
[PDF]
|
|
|
|
|
