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Toxicologic Pathology
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Journal Article

Oral Squamous Cell Carcinoma in Ad Libitum-Fed and Food-Restricted Brown-Norway Rats

J. Dale Thurman

Pathology Associates, Inc., 3900 NCTR Road, Jefferson, Arkansas 72079

David L. Greenman

National Center for Toxicologic Research, 3900 NCTR Road, Jefferson, Arkansas 72079

Ralph L. Kodell

National Center for Toxicologic Research, 3900 NCTR Road, Jefferson, Arkansas 72079

Angelo Turturro

National Center for Toxicologic Research, 3900 NCTR Road, Jefferson, Arkansas 72079

A high incidence of oral squamous cell carcinoma was present in male and female Brown-Norway rats fed ad libitum or food-restricted dietary formulations. One hundred eighty-nine rats were examined from 4 dietary treatment groups: male ad libitum, male food-restricted, female ad libitum, and female food-restricted. The ad libitum treatment groups for both males and females had significantly more cases of oral squamous cell carcinoma than cohort food-restricted groups. In ad libitum rats, 10 of 47 (21%) males and 15 of 47 (32%) females had oral squamous cell carcinoma, whereas only 4 of 47 (9%) males and 5 of 48 (10%) females in the food-restricted groups were similarly affected. The food-restricted rats lived significantly longer than ad libitum cohorts, so the higher incidence of squamous cell carcinoma was not dependent on extended lifespans. In addition to the dietary influence, a significant difference in oral squamous cell carcinoma incidence occurred between various familial lines. Family lines having representatives in both ad libitum and food-restricted groups had lower oral squamous cell carcinoma incidences in the food-restricted group whether comparing affected litters or individuals. Results suggest that the incidence of oral squamous cell carcinoma in our colony of Brown-Norway rats can be influenced by both the dietary treatment group and genetic predilection within certain pedigrees.

Key Words: Caloric restriction • food restriction • oral cavity • neoplasia • inheritance

Toxicologic Pathology, Vol. 25, No. 2, 217-224 (1997)
DOI: 10.1177/019262339702500212
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