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Mesenchymal Tumors of the Mouse Urinary Bladder with Vascular and Smooth Muscle DifferentiationBIBRA Intranational, Woodmansterne Road, Carshalton, Surrey SM5 4DS, United Kingdom
University of Nebraska Medical Center, 600 South 42nd Street, Omaha, Nebraska 68198-3135, USA
1807 Leadburn Road, Baltimore, Maryland 21204, USA Bifenthrin, a synthetic pyrethroid insecticide/miticide, has been fed to male and female Swiss Webster mice at levels of 0, 50, 200, 500, and 600 ppm in the diet for between 604 and 644 days. Tumors of the urinary bladder were observed and initially reported as leiomyosarcomas. Subsequently, the bladders were reviewed and the tumors showed a pattern of both epithelioid cells and spindle cells forming irregular vascular channels. The tumors appeared to arise from the trigone of the bladder and, in some cases, invaded the bladder wall. No metastases were recorded. The tumor is usually considered rare; however, in this study, it was commonly observed in all groups but predominantly in males. The histogenesis of the tumor is uncertain, but from its pleomorphic histological features, including smooth muscle and vascularity, it is probably derived from vascular mesenchyme.
Key Words: Bifenthrin • insecticide • miticide
Toxicologic Pathology, Vol. 25, No. 3,
268-274 (1997) This article has been cited by other articles:
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