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Toxicologic Pathology
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A Uterine Choriocarcinoma in a Virgin Donryu Rat

Midori Yoshida

Department of Pathology, Sasaki Institute, 2-2, Kanda-Surugadai, Chiyoda-ku, Tokyo 101 Japan, maekawa{at}sasaki.or.jp

Katsuhisa Shiraki

Department of Pathology, Sasaki Institute, 2-2, Kanda-Surugadai, Chiyoda-ku, Tokyo 101 Japan

Kayoko Kudoh

Department of Pathology, Sasaki Institute, 2-2, Kanda-Surugadai, Chiyoda-ku, Tokyo 101 Japan

Jin Ando-Lu

Department of Pathology, Sasaki Institute, 2-2, Kanda-Surugadai, Chiyoda-ku, Tokyo 101 Japan

Masakazu Takahashi

Department of Pathology, Sasaki Institute, 2-2, Kanda-Surugadai, Chiyoda-ku, Tokyo 101 Japan

Akihiko Maekawa

Department of Pathology, Sasaki Institute, 2-2, Kanda-Surugadai, Chiyoda-ku, Tokyo 101 Japan

A uterine choriocarcinoma was found in a 49-wk-old virgin Donryu rat given intrauterine administration of N-ethyl-N'-nitro-N-nitrosoguanidine (ENNG) . The tumor was macroscopically present as a bloody cystic mass and microscopically composed of 2 kinds of cells: small basophilic cells similar to cytotrophoblasts in the rat placenta and large cells with big nuclei resembling giant trophoblasts. The giant cells were positive for 3β-hydroxysteroid dehydrogenase (3β-HSD), although immunohistochemical examination was negative or nonspecific for chorionic gonadotrophins, including β human chorionic gonadotrophin (βhCG), human placental lactogen (hPL), and placental glycoprotein (SP-1), or for placental alkaline phosphatase (ALP). However, the animal exhibited a slight mammotropic status. The results thus suggest a choriocarcinoma nature for this uterine tumor and that the tumor cells secrete a weakly mammotrophic hormone.

Key Words: Uterus • choriocarcinoma • cytotrophoblast • giant trophoblast • virgin rat • 3β-HSD

Toxicologic Pathology, Vol. 25, No. 6, 644-646 (1997)
DOI: 10.1177/019262339702500616
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