This Article Free Full Text (Free PDF) Free References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Halliwell, W. H. Search for Related Content PubMed PubMed Citation Articles by Halliwell, W. H. Social Bookmarking                         What's this?

Submucosal Mesenchymal Tumors of the Mouse Urinary Bladder

Schering-Plough Research Institute, Lafayette, New Jersey 07848

A unique morphologic change has been described in the submucosa of the urinary bladder of mice since the 1950s. These lesions, variously referred to as vegetative changes, reactive lesions, submucosal granulomas, leiomyosarcomas, atypical hemangiosarcomas, or submucosal mesenchymal tumors have been considered rare and of questionable etiology. Although the morphologic criteria are fairly well defined, the pathobiology of the lesion is not well characterized and the previously listed nomenclature reflects this uncertainty. The lesion may not be limited to the urinary bladder, the cell of origin is controversial, the biology is unknown, and whether the lesion is granulomatous, hypertrophy, hyperplasia, metaplasia, or a benign or malignant neoplasm is not well defined. Data compiled from multiple sources are discussed to review the strain of mouse most often affected, sex, age at diagnosis, anatomic location, incidence, descriptive morphology, immunohistochemical staining results, and other features of the submucosal mesenchymal tumor of the mouse urinary bladder. Presented are suggested terminology for the lesion, submucosal mesenchymal tumor of the mouse urinary bladder; the relevance of the tumor for human risk assessment; and discussion of the possible histogenesis of this lesion from primitive mesenchymal cells of the submucosa (lamina propria) of the urinary bladder of mice.

Key Words: Risk assessment • cytokines • histopathology • immunohistochemistry • tumor incidence

Toxicologic Pathology, Vol. 26, No. 1, 128-136 (1998)
DOI: 10.1177/019262339802600115


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				C. A. Picut, C. L. Swanson, R. F. Parker, K. L. Scully, and G. A. Parker The Metrial Gland in the Rat and Its Similarities to Granular Cell Tumors Toxicol Pathol, June 1, 2009; 37(4): 474 - 480. [Abstract] [Full Text] [PDF]

				S. Hamed, H. LaRue, H. Hovington, J. Girard, L. Jeannotte, E. Latulippe, and Y. Fradet Accelerated Induction of Bladder Cancer in Patched Heterozygous Mutant Mice Cancer Res., March 15, 2004; 64(6): 1938 - 1942. [Abstract] [Full Text] [PDF]

				C. Keenan, A. Hughes-Earle, M. Case, B. Stuart, S. Lake, C. Mahrt, W. Halliwell, R. Westhouse, M. Elwell, D. Morton, et al. The North American Control Animal Database: A Resource Based on Standardized Nomenclature and Diagnostic Criteria Toxicol Pathol, January 1, 2002; 30(1): 75 - 79. [Abstract] [PDF]

				M. A. Morelli Industry Viewpoint on Thresholds for Genotoxic Carcinogens Toxicol Pathol, May 1, 2000; 28(3): 396 - 404. [Abstract] [PDF]

				E. Karbe Review Article: "Mesenchymal Tumor" or "Decidual-Like Reaction"? Toxicol Pathol, May 1, 1999; 27(3): 354 - 362. [Abstract] [PDF]

				D. C. Thake Mesenchymal Tumors of Mouse Urinary Bladder: Neoplasm or Reactive Change? Toxicol Pathol, May 1, 1999; 27(3): 363 - 363. [PDF]