This Article Free Full Text (Free PDF) Free References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Calabrese, E. J. Articles by Baldwin, L. A. Search for Related Content PubMed PubMed Citation Articles by Calabrese, E. J. Articles by Baldwin, L. A. Social Bookmarking                   What's this?

Chemical Hormesis: Its Historical Foundations as a Biological Hypothesis

Department of Environmental Health Sciences, School of Public Health, University of Massachusetts, Amherst, Massachusetts

Linda A. Baldwin

Department of Environmental Health Sciences, School of Public Health, University of Massachusetts, Amherst, Massachusetts

Despite the long history of hormesis-related experimental research, no systematic effort to describe its early history has been undertaken. The present paper attempts to reconstruct and assess the early history of such research and to evaluate how advances in related scientific fields affected the course of hormesis-related research. The purpose of this paper is not only to satisfy this gap in current knowledge but also to provide a foundation for the assessment of how the concept of hormetic dose-response relationships may have affected the nature of the bioassay, especially with respect to hazard assessment practices within a modem risk assessment framework.

Key Words: Low dose • stimulation • β-curve

CiteULike    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

				E J Calabrese and L A Baldwin Defining hormesis Human and Experimental Toxicology, February 1, 2002; 21(2): 91 - 97. [Abstract] [PDF]

				D.-S. Bae, C. Gennings, W. H. Carter Jr., R. S. H. Yang, and J. A. Campain Toxicological Interactions among Arsenic, Cadmium, Chromium, and Lead in Human Keratinocytes Toxicol. Sci., September 1, 2001; 63(1): 132 - 142. [Abstract] [Full Text] [PDF]

				C L Alden Safety assessment for non-genotoxic rodent carcinogens: curves, low-dose extrapolations, and mecanisms in carcinogenesis Human and Experimental Toxicology, October 1, 2000; 19(10): 557 - 560. [PDF]

				K P Keenan BSELLE newsletter commentary: does caloric restriction induce hormesis? Human and Experimental Toxicology, June 1, 2000; 19(6): 335 - 337. [PDF]

				D E Stevenson and R L Sielken Jr Are calories responsible for a decline in longevity? Human and Experimental Toxicology, June 1, 2000; 19(6): 348 - 350. [PDF]

				E J Calabrese and L A Baldwin The marginalization of hormesis Human and Experimental Toxicology, January 1, 2000; 19(1): 32 - 40. [Abstract] [PDF]

				E J Calabrese and L A Baldwin Radiation hormesis: its historical foundations as a biological hypothesis Human and Experimental Toxicology, January 1, 2000; 19(1): 41 - 75. [Abstract] [PDF]

				E J Calabrese and L A Baldwin Radiation hormesis: the demise of a legitimate hypothesis Human and Experimental Toxicology, January 1, 2000; 19(1): 76 - 84. [Abstract] [PDF]

				E J Calabrese and L A Baldwin Tales of two similar hypotheses: the rise and fall of chemical and radiation hormesis Human and Experimental Toxicology, January 1, 2000; 19(1): 85 - 97. [Abstract] [PDF]

				E. J. Calabrese and L. A. Baldwin The Marginalization of Hormesis Toxicol Pathol, March 1, 1999; 27(2): 187 - 194. [Abstract] [PDF]