Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
Toxicologic Pathology
This Article
Right arrow Free Full Text (Free PDF) Free
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Miyajima, R.
Right arrow Articles by Enomoto, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Miyajima, R.
Right arrow Articles by Enomoto, M.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Eosinophilic Granulated Cells Comprising a Tumor in a Fischer Rat

Rumiko Miyajima

Biosafety Research Center, Foods, Drugs and Pesticides (An-Pyo Center), Shizuoka, Japan

Masayo Hosoi

Biosafety Research Center, Foods, Drugs and Pesticides (An-Pyo Center), Shizuoka, Japan

Shinji Yamamoto

Biosafety Research Center, Foods, Drugs and Pesticides (An-Pyo Center), Shizuoka, Japan

Shin-Ichi Mikami

Biosafety Research Center, Foods, Drugs and Pesticides (An-Pyo Center), Shizuoka, Japan

Seiki Yamakawa

Biosafety Research Center, Foods, Drugs and Pesticides (An-Pyo Center), Shizuoka, Japan

Hijiri Iwata

Biosafety Research Center, Foods, Drugs and Pesticides (An-Pyo Center), Shizuoka, Japan

Makoto Enomoto

Biosafety Research Center, Foods, Drugs and Pesticides (An-Pyo Center), Shizuoka, Japan

A systemic tumor developed in multiple organs, including spleen, bone marrow, lymph nodes, liver, ovaries, and thoracic and lumbar vertebrae, of a female F344Du/Crj rat. The tumor was composed of round to indented mononuclear cells containing abundant large eosinophilic granules in the cytoplasm. The peripheral blood smear revealed that the large granules in the cytoplasm of the tumor cells were stained basophilic with Giemsa, suggesting a basophil or mast cell origin. However, these granules did not show metachromasia with toluidine blue and were stained blue to dark blue with phosphotungstic acid hematoxylin. Cellular morphology and characteristics in the specific stains of tumor cells suggested the development of a tumor of globule leukocytes in a F344Du/Crj rat.

Key Words: Globule leukocyte • mast cell tumor • LGL leukemia

Toxicologic Pathology, Vol. 27, No. 2, 233-236 (1999)
DOI: 10.1177/019262339902700210
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?


This article has been cited by other articles:


Home page
 Vet PatholHome page
M. Nagatani, A. Nakamura, Y. Yamaguchi, T. Aikawa, and K. Tamura
Spontaneous Eosinophilic Granulated Round Cell Tumors in Rats
Vet. Pathol., May 1, 2001; 38(3): 317 - 324.
[Abstract] [Full Text] [PDF]