Toxicologic Pathology

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Click here to sign up for SAGE Journal Email Alerts today!

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Free Full Text (Free PDF) Free
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Long, P. H.
Right arrow Articles by Nyska, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Long, P. H.
Right arrow Articles by Nyska, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Toxicologic Pathology, Vol. 28, No. 2, 246-252 (2000)
DOI: 10.1177/019262330002800204

Dental Pulp Infarction in Female Rats Following Inhalation Exposure to 2-Butoxyethanol

Philip H. Long

Procter & Gamble Pharmaceuticals, Mason, Ohio 45040, long.ph{at}pg.com

Robert R. Maronpot

National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709

Burhan I. Ghanayem

National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709

Joseph H. Roycroft

National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709

Abraham Nyska

National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709

Female Fischer 344 (F344)/N rats (10 per exposure group) were exposed to 2-butoxyethanol (BE) vapors (0, 31, 62.5, 125, 250, or 500 ppm 6 h/d, 5 d/wk, for 13 weeks) to characterize its prechronic toxicity. Dental lesions consisting of bilateral multifocal dental pulp thrombosis, pulp infarction, and odontoblast infarction were noted in the maxillary incisors of 3 of 4 rats from the 500-ppm group that were sacrificed when moribund during the first week of exposure. In addition, 1 rat from the 500-ppm group that was sacrificed on day 32 had similar unilateral incisor lesions but with additional findings consistent with a unilateral maxillary incisor fracture. In contrast, rats sacrificed after 13 weeks of exposure lacked dental lesions. In conclusion, BE has the potential to cause pulp thrombosis and odontoblast infarction in female rats. The apparent variability in response to BE noted in moribund sacrificed vs terminally sacrificed rats was attributed to development of tolerance to BE-induced hemolysis and subsequent incisor regeneration.

Key Words: Rat • 2-butoxyethanol • dental pulp • thrombosis • infarction


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?


This article has been cited by other articles:


Home page
 Toxicol PatholHome page
D. N. Lewis, A. Nyska, K. Johnson, D. E. Malarkey, S. Ward, M. Streicker, S. Shabat, S. Peddada, and M. Nyska
2-Butoxyethanol Female-Rat Model of Hemolysis and Disseminated Thrombosis: X-Ray Characterization of Osteonecrosis and Growth-Plate Suppression
Toxicol Pathol, February 1, 2005; 33(2): 272 - 282.
[Abstract] [Full Text] [PDF]