Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Sign In to gain access to subscriptions and/or personal tools.
Toxicologic Pathology
This Article
Right arrow Free Full Text (Free PDF) Free
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Right arrow Citing Articles via Scopus
Google Scholar
Right arrow Articles by Kuwamura, M.
Right arrow Articles by Kotani, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kuwamura, M.
Right arrow Articles by Kotani, T.
Social Bookmarking
Add to CiteULike   Add to Complore   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati   Add to Twitter  
What's this?

Dandy-Walker Like Malformation in a Fischer-344 Rat

Mitsuru Kuwamura

Department of Veterinary Pathology, College of Agriculture, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan

Takeshi Morikawa

Department of Veterinary Pathology, College of Agriculture, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan

Hisae Yasui

Department of Veterinary Pathology, College of Agriculture, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan

Jyoji Yamate

Department of Veterinary Pathology, College of Agriculture, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan

Takao Kotani

Department of Veterinary Pathology, College of Agriculture, Osaka Prefecture University, Sakai, Osaka 599-8531, Japan

A spontaneous cerebellar malformation was found in a 32-day-old male Fischer 344 rat. The cerebellar malformation was composed of a vermis defect and markedly dilated fourth ventricle. The cerebellar hemispheres were separated, with the left hemisphere being smaller than the right one. Degenerative/inflammatory lesions consisting of macrophage/lymphocyte infiltration, spheroidal calcium depositions, and astrocytic gliosis were seen adjacent to the cerebral aqueduct. Abnormally arranged hyperplastic ependymal cells were observed beneath the fourth ventricle in the medulla oblongata. The gross findings of the present case resemble those of the human Dandy-Walker malformation. While a precise mechanism remains to be elucidated, degenerative/inflammatory lesions in the present rat may be involved in the pathogenesis of this malformation.

Key Words: Cerebellar malformation • vermis defect • fourth ventricle • histopathology • scar lesions • spontaneous

Toxicologic Pathology, Vol. 28, No. 5, 694-696 (2000)
DOI: 10.1177/019262330002800509
Add to CiteULike CiteULike   Add to Complore Complore   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati   Add to Twitter Twitter    What's this?