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Toxicologic Pathology
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Age-Related Cell Proliferation and Apoptosis in the Kidney of Male Fischer 344 Rats With Observations on a Spontaneous Tubular Cell Adenoma

Rosanna Cardani

Dipartimento di Biologia, Facoltà di Scienze, Università di Milano, Via Celoria 26, I-20133, Italy, cardani{at}mailserver.unimi.it

Teresa Zavanella

Dipartimento di Biologia, Facoltà di Scienze, Università di Milano, Via Celoria 26, I-20133, Italy

Cell proliferation rate and apoptosis were examined in archival kidneys from young, middle-aged, and old male F344 rats. Immunohistochemical expression of proliferating cell nuclear antigen (PCNA) and apoptosis were quantified in the same cell populations of the proximal tubule epithelium. A total of 79 kidneys from 40 rats were examined. There was a progressive increase in cell proliferation rates in rats from 4 and 6-10 months of age. In 23-month-old rats, proliferative activity appeared to be reduced. No age-related variations in apoptotic indices were found. One of the 16 rats aged 23 months had a tubular cell adenoma. In the tumor-affected kidney, cell proliferation rate was dramatically higher than in the contralateral kidney as well as in all the other kidneys examined. This high proliferative activity was not balanced by variation in cell death.

Key Words: Cell proliferation • apoptosis • spontaneous tumor • age-related changes • kidney • male F344 rat

Toxicologic Pathology, Vol. 28, No. 6, 802-806 (2000)
DOI: 10.1177/019262330002800606
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