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Toxicologic Pathology
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Case Report: Carcinoma of the Extraorbital Lacrimal Gland in a Female Fischer 344 Rat

James E. Heath

Southern Research Institute, Birmingham, Alabama, heath{at}serquest.com

F. Rahemtullah

University of Alabama at Birmingham, Birmingham, Alabama

W. David Fine

University of Alabama at Birmingham, Birmingham, Alabama

A large subcutaneous mass was observed at necropsy in the right neck area of a 95-week-old female Fischer 344 rat that served as an untreated control animal in a 2-year carcinogenicity study. Formalin-fixed, paraffin-embedded sections of the mass were stained with hematoxylin and eosin along with the immunohistochemical biomarkers lactoperoxidase, catalase, and amylase. Based on its histomorphological and immunohistochemical features, the lesion was diagnosed as a carcinoma of the extraorbital lacrimal gland.

Key Words: Neoplasm • rat • lacrimal gland • immunocytochemistry • spontaneous

Toxicologic Pathology, Vol. 28, No. 6, 824-826 (2000)
DOI: 10.1177/019262330002800608
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