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Toxicologic Pathology
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*Ovarian Cancer
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Malignant Theca Cell Tumor of Rat

Kiyokazu Ozaki

Research Institute of Drug Safety, Setsunan University, 45-1 Nagaotohge-cho, Hirakata, Osaka 573-0101, Japan, ozaki{at}pharm.setsunan.ac.jp

Isao Narama

Research Institute of Drug Safety, Setsunan University, 45-1 Nagaotohge-cho, Hirakata, Osaka 573-0101, Japan

A large-sized ovarian tumor of theca cell origin was found in a female rat. The mass was located in the right ovary position. Histologically, the tumor was covered by thin fibrous capsule and consisted of a solid area and an abundant necrotic area. Tumor cells were arranged in a storiform or whorled pattern. Connective tissue elements occasionally presented as bundles of dense collagen fibers. Fusiform to elongated cells had oval- to spindle-shaped nuclei with indistinct nucleoli. Large round nuclei and mitotic figures were scattered throughout the tumor cells. These cells were stained positively with S-100 but negatively with vimentin and {alpha}—smooth muscle actin. Tumor cells with abundant cytoplasm sometimes contained multiple small-sized lipid vacuoles.

Key Words: Theca cell tumor • rat • tumor • ovary

Toxicologic Pathology, Vol. 28, No. 6, 829-831 (2000)
DOI: 10.1177/019262330002800610
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