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Toxicologic Pathology
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Reproductive Endocrinology and Toxicological Pathology over the Life Span of the Female Rodent

Barbara J. Davis

Laboratory of Women's Health, NIEHS, Research Triangle Park, North Carolina, Davis1{at}niehs.nih.gov

Gregory Travlos

Laboratory of Experimental Pathology, NIEHS, Research Triangle Park, North Carolina

Teresa McShane

Comparative Medicine Branch, NIEHS, Research Triangle Park, North Carolina

Understanding the pathology of the female reproductive system with respect to toxicology requires a basic understanding of morphology and function of the system over time because the nature of the female reproductive system is cyclical. Thus, the morphology and the endocrinology is dependent on age and time, as form follows function and function follows form. The life span of the rodent is used as an outline to present an overview of key morphological and endocrinological events important for toxicologic pathologists to consider in study evaluations. Environmental and pharmaceutical compounds differentially impact the organs individually and/or the system in its entirety in a time- and dose-dependent way. Examples are used to illustrate the consequences of exposures at different times and with different outcomes.

Key Words: Rat • mouse • female reproduction • ovary • uterus • vagina • cyclicity • hormones

Toxicologic Pathology, Vol. 29, No. 1, 77-83 (2001)
DOI: 10.1080/019262301301418874
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