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Toxicologic Pathology, Vol. 29, No. 1 suppl, 5-12 (2001)
DOI: 10.1080/019262301753178429

Assessment of Human Cancer Risk: Challenges for Alternative Approaches

Gilbert S. Omenn

The University of Michigan, Ann Arbor, Michigan

The ILSI/HESI Workshopon Alternatives to Carcinogenicity Testing aims to develop and apply new methods for assessment of potential carcinogenic risk to humans from various chemicals. The Workshoprepresents a major cooperative scientific effort. The long-term goals should be to greatly enhance the effi ciency and reliability of such testing and to supplant, not just supplement, lifetime rodent bioassays. There are now well-established frameworks for risk assessment and risk management, putting risks into public health context and engaging stakeholders. The Lave-Omenn value-of-information model provides a useful way to assess the social costs and benefits of different strategies for testing large numbers of chemicals.

Key Words: Cancer risk assessment • risk management • cost-effectiveness analysis • public health context • value-of-information model • social costs.


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