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Toxicologic Pathology
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*1-FLUORO-2,4-DINITROBENZENE
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Suppressive Effects on Allergic Contact Dermatitis by Short-Term Fasting

Harunobu Nakamura

Department of Public Health, Hamamatsu University School of Medicine, 3600 Handa, Hamamatsu, Shizuoka 431-3192, Japan, hal{at}hama-med.ac.jp

Katsuyasu Kouda

Department of Public Health, Hamamatsu University School of Medicine, 3600 Handa, Hamamatsu, Shizuoka 431-3192, Japan

Wenying Fan

Department of Public Health, Hamamatsu University School of Medicine, 3600 Handa, Hamamatsu, Shizuoka 431-3192, Japan

Tomoyuki Watanabe

Research & Development Division, Sumika Technoservice Corporation, 3-1-98 Kasugadenaka, Konohana-ku, Osaka 554-8558, Japan

Hiroichi Takeuchi

Department of Public Health, Hamamatsu University School of Medicine, 3600 Handa, Hamamatsu, Shizuoka 431-3192, Japan

Fasting alters various hormonal and immune conditions. It has been reported that delayed type immune response to the injection of keyhole limpet hemocyanin was depressed by short-term fasting. In this study, we adopted the computer-assisted image analyzer for histopathological analysis and evaluated the infl uence of short-term fasting on allergic contact dermatitis induced by 2,4-dinitrofluorobenzene (DNFB). Mice were sensitized by painting of DNFB to the abdomen. After the sensitization, mice were challenged by DNFB painting to the ear. Fasting started 24 hour before (48-hour fasted group) or immediately after (24-hour fasted group) the challenging. Fasting without DNFB treatment did not induce remarkable change of ear thickness, ear tissue, serum albumin, serum total protein, serum glutamic oxaloacetic transaminase, serum glutamic pyruvic transaminase, or serum creatine phosphokinase. In contrast, fasting suppressed the increment of ear thickness in the DNFB-treated group in this study. We could also demonstrate, using the computerized image analyzer, that both lymphocyte infi ltration and the edema in the dermis were suppressed in fasted mice treated with DNFB. Further, edema in the dermis was inhibited more strongly in 48-hour fasted mice than in 24-hour fasted mice. These fi ndings indicate that short-term fasting induce histopathological changes in the state of contact dermatitis.

Key Words: Computer-assisted image processing • contact eczema • delayed type hypersensitivity • dinitrofluorobenzene • mice • starvation.

Toxicologic Pathology, Vol. 29, No. 2, 200-207 (2001)
DOI: 10.1080/019262301317052477
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