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Toxicologic Pathology
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Pulmonary Function in Nonsmokers Following Exposure to Sidestream Cigarette Smoke

Carr J. Smith

Research and Development, Bowman Gray Technical Center, R. J. Reynolds Tobacco Company, Winston-Salem, NC 27102-1487

David W. Bombick

Research and Development, Bowman Gray Technical Center, R. J. Reynolds Tobacco Company, Winston-Salem, NC 27102-1487

Brett A. Ryan

Research and Development, Bowman Gray Technical Center, R. J. Reynolds Tobacco Company, Winston-Salem, NC 27102-1487

Michael J. Morton

Research and Development, Bowman Gray Technical Center, R. J. Reynolds Tobacco Company, Winston-Salem, NC 27102-1487

David J. Doolittle

Research and Development, Bowman Gray Technical Center, R. J. Reynolds Tobacco Company, Winston-Salem, NC 27102-1487

Ten healthy male and 10 healthy female, "never-smoking" subjects (ages 21—50) participated in a 5-day environmental room study to determine if an acute exposure to a high level of fresh diluted sidestream smoke (FDSS) would alter pulmonary function. On Monday, Tuesday, Thursday and Friday, the twenty subjects sat in an environmental room for 7.33 hours and were exposed to fi ltered and humidified air. On Wednesday, the twenty subjects were exposed in an environmental room for 7.33 hours to an average respirable suspended particle (RSP) concentration of 179 micrograms per m3 of FDSS generated by machine smoking Kentucky 1R4F reference cigarettes. This level of FDSS is 3.3 times the 95th percentile concentration of workplace environmental tobacco smoke exposure levels previously measured in the US. FVC and FEV1 decreased approximately 1.6% (p < 0.05) in both males and females after exposure. Similarly, PEF decreased approximately 1.3% (p < 0.03) following exposure. The observed decrease in pulmonary function was consistent with a "stress" related norepinephrine-induce d alteration in blood flow leading to transient bronchoconstriction. Alternatively, a cholinergic refl ex due to activation of bronchopulmonar y C fibers may have also played a role in the transient bronchoconstriction. These small exposure-related decrements in pulmonary function were reversible.

Key Words: Environmental tobacco smoke • pulmonary function.

Toxicologic Pathology, Vol. 29, No. 2, 260-264 (2001)
DOI: 10.1080/019262301317052549
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