Toxicologic Pathology

 

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Toxicologic Pathology, Vol. 29, No. 4, 492-497 (2001)
DOI: 10.1080/01926230152499980

Analysis of Toxic Effects of Alternaria Toxins on Esophagus of Mice by Light and Electron Microscopy

Hayreddin Yekeler

Department of Pathology Medical School, Firat University, Elazig, Turkey

Kazim Bitmis

Department of Biology Science and Art Faculty, Firat University, Elazig, Turkey

Nurten Ozçelik

Department of Med. Biology Medical School, Süleyman Demirel University, Isparta, Turkey

Mehmet Z. Doymaz

Department of Microbiology Medical School, Firat University, Elazig, Turkey, doymaz{at}firat.edu.tr.

Metin Çalta

Department of Bas. Aquatic Sciences Fisheries Faculty, Firat University, Elazig, Turkey

In this study, the possible toxic effects of Alternariol Methyl Ether (AME) and Tenuazonic Acid (TeA) produced by Alternaria species on esophagus of mice were investigated by using light and electron microscopy techniques. Mice were orally fed daily with AME or TeA for 10 months and at the end of this period, the effects of these chemicals on the esophageal mucosa were determined. By light microscopic examination, moderate and severe dysplasia characterized by loss of polarity, nuclear pleomorphism, and hyperchromasi a were observed in TeA-treated animals. Electron-microscopi c examination of TeA-treated mucosal epithelial cells revealed pyknosis in some nuclei, granulation and increase in chromatin mass, irregularities in the nuclear contours, vacuolization in nucleoplasms, and marked pleomorphism in the nuclei. In conclusion, our results suggested that TeA has higher toxicity as evidenced by dysplastic transformation.

Key Words: Alternariol methyl ether • histopathology • mycotoxin • tenuazonic acid.


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